| 阿托伐他汀内酯的波谱学数据与结构确证 |
| |
| 引用本文： | 吴春丽,李杰明,魏会杰,蒋月明,杭晔,陈新丽,朱凯.阿托伐他汀内酯的波谱学数据与结构确证[J].波谱学杂志,2014,31(2):268-277. |
| |
| 作者姓名： | 吴春丽 李杰明 魏会杰 蒋月明 杭晔 陈新丽 朱凯 |
| |
| 作者单位： | 郑州大学 药学院，河南 郑州 450001 |
| |
| 摘 要： | 对阿托伐他汀内酯的紫外吸收光谱(UV)、红外吸收光谱(IR)、质谱(MS)、核磁共振氢谱(1H NMR)、氢-氢相关谱(1H-1H COSY)、核磁共振碳谱(13C NMR)、DEPT谱、异核单量子相关谱(HSQC)、异核多键相关谱(HMBC)报道并进行了解析,对其所有的NMR谱信号进行了归属,同时讨论了质谱的主要碎片离子的可能的裂解方式和红外特征吸收峰所对应的官能团的振动形式.通过多种波谱技术确证了阿托伐他汀钙内酯的结构.
|
| 关 键 词： | 核磁共振(NMR) 归属 化学位移 阿托伐他汀内酯 结构确证 |
| 收稿时间： | 2013-05-07 |
Spectral Analysis and Structural Elucidation of Atorvastatin Lactone |
| |
| WU Chun-li,LI Jie-ming,WEI Hui-jie,JIANG Yue-ming,HANG Ye,CHEN Xin-li,ZHU Kai.Spectral Analysis and Structural Elucidation of Atorvastatin Lactone[J].Chinese Journal of Magnetic Resonance,2014,31(2):268-277. |
| |
| Authors: | WU Chun-li LI Jie-ming WEI Hui-jie JIANG Yue-ming HANG Ye CHEN Xin-li ZHU Kai |
| |
| Institution: | School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China |
| |
| Abstract: | Ultraviolet spectrum, infrared spectrum, mass spectra and nuclear magnetic resonance spectra of atorvastatin lactone were collected and interpreted. All the NMR signals were assigned. Based on the mass spectral data, the possible fragmentation pathways were discussed. The infrared spectrum was used to analyze the types of vibration of the functional groups in this compound. The structure of the compound was determined. |
| |
| Keywords: | NMR assignment chemical shift atorvastatin lactone structural elucidation |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《波谱学杂志》浏览原始摘要信息 |
| 点击此处可从《波谱学杂志》下载免费的PDF全文 |
|
