| A Versatile Approach for the Asymmetric Synthesis of 3-Alkyl-isoindolin-1-ones |
| |
| 作者姓名： | 陈明德 贺明珠 黄利强 阮源萍 黄培强 |
| |
| 作者单位： | CHEN，Ming-De HE，Ming-Zhu HUANG，Li-Qiang RUAN，Yuan-Ping HUANG，Pei-Qiang Department of Chemistry，Xiamen University，Xiamen，Fujian 361005，China |
| |
| 基金项目： | theNationalNaturalScienceFoundationofChina (Nos.2 9832 0 2 0and 2 0 0 72 0 31) |
| |
| 摘 要： | 3 Ｓｕｂｓｔｉｔｕｔｅｄｉｓｏｉｎｄｏｌｉｎ 1 ｏｎｅｓ (2 ,3 ｄｉｈｙｄｒｏ 1Ｈ ｉｓｏｉｎｄｏｌｉｎ 1 ｏｎｅｓ)ｏｆｇｅｎｅｒａｌｓｔｒｕｃｔｕｒｅ (1)ｃｏｎｓｔｉｔｕｔｅｔｈｅｋｅｙｓｔｒｕｃｔｕｒａｌｆｅａｔｕｒｅｏｆａｌａｒｇｅｎｕｍｂｅｒｏｆｂｉｏａｃｔｉｖｅｍｏｌｅｃｕｌｅｓｏｆｎａｔｕｒａｌｏｒｓｙｎｔｈｅｔｉｃｏｒｉｇｉｎ .Ｆｏｒｅｘａｍｐｌｅ ,ｌｅｎｎｏｘａｍｉｎｅ (2 ) ,1ｎｕｅｖａｍｉｎｅａｎｄｃｈｉｌｅｎｉｎｅａｒｅａｌｋａｌｏｉｄｓｉｓｏｌａｔｅｄｆｒｏｍｖａｒｉｏｕｓ…
|
A Versatile Approach for the Asymmetric Synthesis of 3-Alkyl-isoindolin-1-ones |
| |
| CHEN,Ming-De HE,Ming-Zhu HUANG,Li-Qiang RUAN,Yuan-Ping HUANG,Pei-Qiang.A Versatile Approach for the Asymmetric Synthesis of 3-Alkyl-isoindolin-1-ones[J].Chinese Journal of Chemistry,2002,20(11):1149-1153. |
| |
| Authors: | CHEN Ming-De HE Ming-Zhu HUANG Li-Qiang RUAN Yuan-Ping HUANG Pei-Qiang |
| |
| Institution: | CHEN,Ming-De HE,Ming-Zhu HUANG,Li-Qiang RUAN,Yuan-Ping HUANG,Pei-Qiang Department of Chemistry,Xiamen University,Xiamen,Fujian 361005,China |
| |
| Abstract: | A flexible approach to (R)-3-alkyl-isoindolin-1-ones and (R)-3-aryl-isoindolin-1-ones via a diastereoselective reductive-alkylation is described. Present method is versatile in scope, allowing the easy introduction of various C-3 substituents by Grignard addition to phthalimide derived from (R)-phenylglycinol. 3-Alkyl-3-hydroxy-isoindolin-1-ones can also be obtained in the first step of the present method. |
| |
| Keywords: | isoindolin-1-one asymmetric synthesis phenylglycinol reductive alkylation phthalimide |
| 本文献已被 CNKI 等数据库收录！ |
