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Novel ‘Nano in Nano’ Composites for Sustained Drug Delivery: Biodegradable Nanoparticles Encapsulated into Nanofiber Non‐Wovens |
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| Authors: | Moritz Beck‐Broichsitter Marcel Thieme Juliane Nguyen Thomas Schmehl Tobias Gessler Werner Seeger Seema Agarwal Andreas Greiner Thomas Kissel |
| Institution: | 1. Department of Pharmaceutics and Biopharmacy, Philipps‐Universit?t Marburg, 35037 Marburg, Germany;2. Medical Clinic II, Department of Internal Medicine, Justus‐Liebig‐Universit?t Giessen, 35392 Giessen, Germany;3. Department of Chemistry and Scientific Center for Materials Science, Philipps‐Universit?t Marburg, 35032 Marburg, Germany |
| Abstract: | Novel ‘nano in nano’ composites consisting of biodegradable polymer nanoparticles incorporated into polymer nanofibers may efficiently modulate drug delivery. This is shown here using a combination of model compound‐loaded biodegradable nanoparticles encapsulated in electrospun fibers. The dye coumarin 6 is used as model compound for a drug in order to simulate drug release from loaded poly(lactide‐co‐glycolide) nanoparticles. Dye release from the nanoparticles occurs immediately in aqueous solution. Dye‐loaded nanoparticles which are encapsulated by electrospun polymer nanofibers display a significantly retarded release.  |
| Keywords: | biodegradable composite materials controlled drug delivery nanoparticles nanofiber non‐wovens |