Polyisobutylene‐based polyurethanes. V. Oxidative‐hydrolytic stability and biocompatibility |
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Authors: | Jungmee Kang Gabor Erdodi Christopher M Brendel Daniel Ely Joseph P Kennedy |
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Institution: | 1. Institute of Polymer Science, The University of Akron, Akron, Ohio 44325‐3909;2. Department of Biology, The University of Akron, Akron, Ohio 44325‐3909 |
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Abstract: | The oxidative/hydrolytic stability of polyurethanes (PUs) containing exclusively polyisobutylene (PIB), or mixed PIB/polytetramethylene oxide (PTMO), or mixed PIB/polyhexamethylene carbonate (PC) soft segments was investigated. The tensile strengths and elongations of various PUs were determined before and after agitating in 35% HNO3 or 20% H2O2/0.1 M CoCl2 solutions and retentions were quantified. The presence of PIB imparts significant oxidative/hydrolytic resistance. The tensile strength and elongation of PUs containing 70% PIB, or those of mixed PIB/PC soft segments with 50% PIB, remained essentially unchanged upon exposure to HNO3; in contrast, PUs containing mixed PIB/PTMO soft segments with 50% PIB underwent significant degradation. The tensile strength of PUs with mixed PIB/PC (60/10%) soft segment increased after exposure to HNO3, most likely because of oxidative crosslinking of PC segments. PIB/PTMO‐ and PIB/PC‐based PUs and commercially available PUs (Elast‐Eon® and Carbothane®) were exposed to H2O2/CoCl2 solutions for up to 14 weeks. Although the experimental PIB/PC‐based PUs exhibited negligible change in mechanical properties and no surface damage, Elast‐Eon® and Carbothane® showed significant surface damage. PIB‐based polyureas and Bionate® were implanted in rats for 4 weeks in vivo, and their biocompatibility was investigated. The biocompatibility of PIB‐based materials was superior to Bionate®. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 2194–2203, 2010 |
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Keywords: | biocompatibility biomaterials oxidative/hydrolytic stability polyisobutylene polyurethanes |
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