Electrochemical behavior and differential pulse voltammetric determination of paracetamol at a carbon ionic liquid electrode |
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Authors: | Xiaodong ShangGuan Hongfang Zhang Jianbin Zheng |
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Institution: | (1) Institute of Analytical Science, Shaanxi Provincial Key Lab of Electroanalytical Chemistry, Northwest University, Xi’an, Shaanxi, 710069, China |
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Abstract: | The electrochemical behavior of paracetamol in 0.1 M acetate buffer solution (pH 4.6) was investigated at a traditional carbon
paste electrode (TCPE) and a carbon ionic liquid electrode (CILE) fabricated by replacing nonconductive organic binders with
a conductive hydrophobic room temperature ionic liquid, 1-butyl-3-methylimidazolium hexafluorophosphate (BmimPF6). The results showed that the CILE exhibited better reversibility for the electrochemical redox of paracetamol. The oxidation
potential of paracetamol at the CILE is +0.462 V, which is approximately 232 mV lower than that at the TCPE; the oxidation
peak current response is nine times higher than that at the TCPE. The differential pulse voltammetric determination of paracetamol
at the CILE was established based on this behavior. After optimizing several important parameters controlling the performance
of paracetamol at the CILE, the oxidation peak current versus paracetamol concentration at the CILE showed linearity in the
range from 1.0 μM to 2.0 mM (R
2
= 0.9992) with a detection limit of 0.3 μM (S/N = 3). The method has been applied to the determination of paracetamol in
tablets and urine samples and the average recovery of paracetamol was 98.5% and 99.3%, respectively. The proposed CILE showed
good sensitivity and reproducible response without influence of interferents commonly existing in pharmaceutical and urine
samples.
Figure CV curves of paracetamol illustrate the enhanced electrochemical behavior of paracetamol at the CILE (b), which forms the basis for the differential pulse voltammetric determination of paracetamol |
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Keywords: | Voltammetry Ionic liquid Carbon ionic liquid electrode Paracetamol |
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