| 在中性条件下用亚氯酸钠和双氧水氧化芳香醛 |
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| 引用本文： | 田青强,王华均,袁建勇.在中性条件下用亚氯酸钠和双氧水氧化芳香醛[J].化学通报,2017,80(12):1143-1147. |
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| 作者姓名： | 田青强 王华均 袁建勇 |
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| 作者单位： | 重庆医科大学药学院,重庆医科大学药学院,重庆医科大学药学院 |
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| 摘 要： | 本文优化了中性环境中亚氯酸钠和双氧水氧化醛的反应条件，采用正交实验设计法考察了溶剂、亚氯酸钠和双氧水的用量以及反应温度对醛氧化产率的影响，确定最佳工艺条件为以乙醇作溶剂，亚氯酸钠、双氧水、醛的摩尔比为1.1: 2: 1。在优化的反应条件下对醛进行底物扩展验证其适应性，并通过放大实验说明其工业生产适用性，本方法具有产率高、后处理简单、副产物绿色无污染的优点。
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| 关 键 词： | 亚氯酸钠 双氧水 中性条件 氧化 醛 |
| 收稿时间： | 2017/5/11 0:00:00 |
| 修稿时间： | 2017/6/12 0:00:00 |
Oxidation of Aromatic Aldehydes by sodium chlorite and hydrogen peroxide under Neutral Conditions |
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| Tian Qingqiang,Wang Huajun and Yuan Jianyong.Oxidation of Aromatic Aldehydes by sodium chlorite and hydrogen peroxide under Neutral Conditions[J].Chemistry,2017,80(12):1143-1147. |
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| Authors: | Tian Qingqiang Wang Huajun and Yuan Jianyong |
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| Institution: | Pharmacy college,Chongqing medical university,Pharmacy college,Chongqing medical university,Pharmacy college,Chongqing medical university |
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| Abstract: | In this paper, the reaction conditions for the oxidation of aldehydes with sodium chlorite and hydrogen peroxide in neutral environment were optimized. The effects of solvent, amounts of sodium chlorite and hydrogen peroxide and reaction temperature on the yield of acids were investigated by orthogonal experimental design. The optimum conditions were as follows: ethanol as solvent, the molar ratio of sodium chlorite, hydrogen peroxide and aldehyde was 1.1: 2: 1. The adaptability of aldehydes was verified, and the industrial applicability was demonstrated by amplification experiments. It was proved that the method has the characteristics of high yield, simple post-processing, green by-products without pollution, etc. |
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| Keywords: | sodium chlorite hydrogen peroxide Neutral condition Oxidation Aldehyde |
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