Surface-enhanced Raman spectroscopy: substrate-related issues |
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Authors: | Xiu-Mei Lin Yan Cui Yan-Hui Xu Bin Ren Zhong-Qun Tian |
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Institution: | (1) State Key Laboratory for Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China;(2) Research Center of Biomedical Engineering, College of Materials, Xiamen University, Xiamen, 361005, China |
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Abstract: | After over 30 years of development, surface-enhanced Raman spectroscopy (SERS) is now facing a very important stage in its
history. The explosive development of nanoscience and nanotechnology has assisted the rapid development of SERS, especially
during the last 5 years. Further development of surface-enhanced Raman spectroscopy is mainly limited by the reproducible
preparation of clean and highly surface enhanced Raman scattering (SERS) active substrates. This review deals with some substrate-related
issues. Various methods will be introduced for preparing SERS substrates of Ag and Au for analytical purposes, from SERS substrates
prepared by electrochemical or vacuum methods, to well-dispersed Au or Ag nanoparticle sols, to nanoparticle thin film substrates,
and finally to ordered nanostructured substrates. Emphasis is placed on the analysis of the advantages and weaknesses of different
methods in preparing SERS substrates. Closely related to the application of SERS in the analysis of trace sample and unknown
systems, the existing cleaning methods for SERS substrates are analyzed and a combined chemical adsorption and electrochemical
oxidation method is proposed to eliminate the interference of contaminants. A defocusing method is proposed to deal with the
laser-induced sample decomposition problem frequently met in SERS measurement to obtain strong signals. The existing methods
to estimate the surface enhancement factor, a criterion to characterize the SERS activity of a substrate, are analyzed and
some guidelines are proposed to obtain the correct enhancement factor. |
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Keywords: | Silver Gold Substrate preparation Substrate cleaning Photodecomposition Surface enhancement factor |
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