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Synthesis and Characterization of Novel Amphiphilic Polymers as Drug Delivery Nano Carriers |
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| Authors: | Mukesh K Pandey Rahul Tyagi Bhavna Gupta Virinder S Parmar Jayant Kumar Arthur C Watterson |
| Institution: | 1. Institute of Nano-science and Engineering Technology, University of Massachusetts , Lowell, MA;2. Center for Advanced Materials , University of Massachusetts , Lowell, MA;3. Bio-organic Laboratory, Department of Chemistry , University of Delhi , India |
| Abstract: | Polymer nano-particles have been widely investigated in the last decade due to a variety of potential applications. In particular, polymers which can self assemble into micellar nano-particles can be effectively used as vehicles for drug delivery. Considerable efforts are underway to develop better drug delivery nano carriers for high drug loading capacity for a wide variety of bioactive compounds. In this study, several new polymers were synthesized in bulk (solventless condition) by a chemo-enzymatic methodology using Candida antarctica lipase B (Novozyme 435) and molecular sieves (MS). The synthesized polymers demonstrated high drug loading capacity and the potential to encapsulate drugs which are poorly soluble in aqueous solvents. |
| Keywords: | Encapsulation self-assembly amphiphilic polymer nano-particles drug delivery chemo-enzymatic Novozyme-435 Candida antarctica Lipase B static light scattering micelles |