| A Novel Glucose Biosensor Based on Palladium Nanoparticles and Its Application in Detection of Glucose Level in Urine |
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| 作者姓名： | 张芬芬 万巧 李陈鑫 朱自强 鲜跃仲 金利通 山本胜信 |
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| 作者单位： | Department of Chemistry，East China Normal University，Department of Chemistry，East China Normal University，Department of Chemistry，East China Normal University，Department of Electronic Engineering，East China Normal University，Department of Chemistry，East China Normal University，Department of Chemistry，East China Normal University，BAS Co.，Ltd. No.36-4，1-Chome，Oshiage，Sumida-Ku Shanghai 200062，China，Shanghai 200062，China，Shanghai 200062，China，Shanghai 200062，China，Shanghai 200062，China，Shanghai 200062，China，Tokyo 131，Japan |
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| 基金项目： | ProjectsupportedbytheNaturalScienceFoundationofChina (No .2 0 175 0 0 6)andtheSpecialFundationforNanoTechnologyofShanghai (No .0 2 14nm0 78andNo .0 114nm 0 72 ) |
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| 摘 要： | IntroductionThelevelofglucoseinbloodorurineindicateshyper andhypoglycaemia ,bothofwhichcanresultfromavarietyofendocrinedisorders .1 4 Therapidandreliabledetermi nationofglucoselevelisaroutineprojectinclinicchem istry.Urinesamplesaresaferandmoreconvenientthanbloodones .Meanwhile ,theconcentrationofglucoseinserumiscloselyassociatedwiththatinurine .2 4 Eventhoughglucoseelectrodeshavebeensuccessfullyusedinseruminclinicalapplication ,thequestionstillremainedofhowtodetecttheglucoselevelinurine ,wh…
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| 关 键 词： | 葡萄糖 生物传感器 钯 纳米粒子 应用 尿检测 电子催化 葡糖氧化酶 电沉积 |
A Novel Glucose Biosensor Based on Palladium Nanoparticles and Its Application in Detection of Glucose Level in Urine |
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| ZHANG,Fen-Fen a WAN,Qiao a LI,Chen-Xin aZHU,Zi-Qiang b XIAN,Yue-Zhong a JIN,Li-Tong,a YAMAMOTO,Katsunobu c a.A Novel Glucose Biosensor Based on Palladium Nanoparticles and Its Application in Detection of Glucose Level in Urine[J].Chinese Journal of Chemistry,2003,21(12):1619-1623. |
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| Authors: | ZHANG Fen-Fen a WAN Qiao a LI Chen-Xin aZHU Zi-Qiang b XIAN Yue-Zhong a JIN Li-Tong a YAMAMOTO Katsunobu c a |
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| Institution: | ZHANG,Fen-Fen a WAN,Qiao a LI,Chen-Xin aZHU,Zi-Qiang b XIAN,Yue-Zhong a JIN,Li-Tong,a YAMAMOTO,Katsunobu c a Department of Chemistry,East China Normal University,Shanghai 200062,China b Department of Electronic Engineering,East China Normal University,Shanghai 200062,China c BAS Co.,Ltd. No.36-4,1-Chome,Oshiage,Sumida-Ku,Tokyo 131,Japan |
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| Abstract: | A novel glucose biosensor was constructed by electrodeposition of highly dispersed palladium (Pd) nanoparticles on a glassy carbon electrode (GCE). Atomic force microscopy (AFM) was applied to characterize its surface morphology. Electrodeposited Pd nanoparticles exhibited efficiently electrocatalytic oxidation for hydrogen peroxide (H2O2) with relatively high sensitivity and stability, which was studied by CV technique and Raman spectroscopy, respectively. The GC/PdVGOD/Nafion system allowed a low working potential of +0.3 V (vs. SCE). Its signal current was linearly related to the glucose concentration in the range of 1.0 × 10–6‐1.2 × 10–4mol × L?1 with a detection limit of 5.0 × 10–7 mol · L?1. The sensor required no special pretreatment to suppress interference from urate and L‐ascorbate. It was successfully used in detection of glucose level in human urine with high stability, sensitivity and anti‐poisoning ability. |
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| Keywords: | palladium nanoparticle electrocatalyze hydrogen peroxide glucose oxidase |
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