Electrochemical Behaviour of Carbamazepine in Acetonitrile and Dimethylformamide Using Glassy Carbon Electrodes and Microelectrodes |
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Authors: | S Atkins J M Sevilla M Blazquez T Pineda J Gonzalez‐Rodriguez |
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Institution: | 1. School of Natural and Applied Sciences, University of Lincoln, Brayford Pool, Lincoln, LN6?7TS, UK;2. Departamento de Quimica Fisica y Termodinamica Aplicada, Universidad de Cordoba, Campus de Rabanales, Ed. Marie Curie, E‐14071 Cordoba, Spain |
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Abstract: | The electrochemical reduction of carbamazepine in acetonitrile (ACN) and dimethylformamide (DMF) using a glassy carbon electrode and microelectrodes has been studied. The reduction process is consistent with an electrochemical‐chemical mechanism (EC) involving a two electron transfer followed by a first order reaction, as shown by the cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Half‐wave potential, number of electron transferred, diffusion coefficient and rate constant of the associated chemical reaction are reported. Limits of detection (LOD) for DPV are 0.92 and 0.76 µg mL?1 (3.89×10?6 mol L?1 and 3.21×10?6 mol L?1) in ACN and DMF, respectively. Precision (%RSD) and recovery (%) values when pharmaceutical compounds (200mg carbamazepine tablets) and spiked plasma samples were tested ranged from 1.09 to 9.04 % and % recoveries ranged from 96 to 104.1 %. |
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Keywords: | Carbamazepine Glassy carbon electrode Microelectrodes Voltammetry |
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