Development of a General and Selective Nanostructured Cobalt Catalyst for the Hydrogenation of Benzofurans,Indoles and Benzothiophenes |
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Authors: | Bei Zhou Dr Vishwas G Chandrashekhar Dr Zhuang Ma Dr Carsten Kreyenschulte Dr Stephan Bartling Dr Henrik Lund Prof Dr Matthias Beller Prof Dr Rajenahally V Jagadeesh |
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Institution: | Leibniz-Institut für Katalyse e.V., Albert-Einstein-Str. 29a, 18059 Rostock, Germany |
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Abstract: | The selective hydrogenation of benzofurans in the presence of a heterogeneous non-noble metal catalyst is reported. The developed optimal catalytic material consists of cobalt-cobalt oxide core–shell nanoparticles supported on silica, which has been prepared by the immobilization and pyrolysis of cobalt-DABCO-citric acid complex on silica under argon at 800 °C. This novel catalyst allows for the selective hydrogenation of simple and functionalized benzofurans to 2,3-dihydrobenzofurans as well as related heterocycles. The versatility of the reported protocol is showcased by the reduction of selected drugs and deuteration of heterocycles. Further, the stability, recycling, and reusability of the Co-nanocatalyst are demonstrated. |
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Keywords: | Benzofurans Benzothiophenes Hydrogenation Indoles Nanocatalyst |
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