| 天冬酰胺的环化缩合反应及其在合成拮抗剂与吗啡肽中的应用 |
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| 引用本文： | 魏运洋.天冬酰胺的环化缩合反应及其在合成拮抗剂与吗啡肽中的应用[J].应用化学,2004,21(1):70-0. |
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| 作者姓名： | 魏运洋 |
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| 作者单位： | 南京理工大学 |
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| 摘 要： | 天冬酰胺的环化缩合反应及其在合成拮抗剂与吗啡肽中的应用;四氢嘧啶酮;构象;内源性吗啡肽
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| 关 键 词： | 天冬酰胺的环化缩合反应及其在合成拮抗剂与吗啡肽中的应用 四氢嘧啶酮 构象 内源性吗啡肽 |
| 文章编号： | 1000-0518(2004)01-0070-06 |
| 收稿时间： | 2009-06-29 |
| 修稿时间： | 2003年3月25日 |
Cyclization of Asparagine and Its Applications in the Synthesis of Chlesystokynin and Endomorphin Analogues |
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| WEI Yun-Yang.Cyclization of Asparagine and Its Applications in the Synthesis of Chlesystokynin and Endomorphin Analogues[J].Chinese Journal of Applied Chemistry,2004,21(1):70-0. |
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| Authors: | WEI Yun-Yang |
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| Abstract: | A series of compounds containing tetrahydropyrimidinone ring were synthesized via condensation of asparagine t -butyl ester with aromatic aldehydes and amino acid chlorides. Conformational isomer ratio of the products and the activation free energy for conformational transformation between isomers were determined by dynamic 1H NMR spectroscopy. Reaction of the Fmoc-deprotected compounds containing tetrahydropyrimidinone ring with m -tolyl isocyanate provided some chlesystokynin analogues. Two endomorphin derivatives were also synthesized from a compound containing tetrahydropyrimidinone ring and the proper dipeptides. |
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| Keywords: | asparagine tetrahydropyrimidinone conformation antagonist endomorphin |
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