| A new bioactive prenylated dihydroflavanoid from Dolichos tenuicaulis （Baker） Craib |
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| 作者姓名： | Jin Yong Peng Hal Yan Liu Yan Qi Xu Han You Wei Xu Li Na Xu Qi Wei Xu |
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| 作者单位： | [1]School of Pharmacy, Dalian Medical University, Dalian 116027, China [2]People＇s Hospital of the State of Xishuangbanna, Yunnan 666100, China |
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| 基金项目： | Acknowledgments The authors thank Dr. Genjin Yang （Second Military Medical University, Shanghai, China） for his performing 1D and 2D NMR experiments. |
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| 摘 要： | A new prenylated dihydroflavonoid was obtained from the root of Dolichos tenuicaulis （Baker） Craib. The structure was elucidated as （2S）-5,2＇,6＇-trihydroxy-3＇″, 8-di （γ,γ-dimethyl-allyl）-2＇″, 2＇″-dimethylpyrano-5＇″,6＇″： 6,7]-2＇″″,4＇″″-cyclohexadiene-1 ＇″″-one-2＇″″,3＇″″： 3＇,4＇]-flavanone, named dolichnin A, by spectroscopic methods including UV, IR, HR-EI-MS, 1D NMR and 2D NMR techniques, and subsequently, the anticancer activity of this compound to inhibit human cancer cells＇ growth including A549, BEL-7402, Hep-3B, SMMC7721, HT-29, MCF-7, SGC-7902, K562, A498 and PC3 cell lines by MTT method was evaluated in vitro.
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| 关 键 词： | 中草药 扁豆 化学成分 异戊烯化二氢类黄酮 抗癌活性 |
| 收稿时间： | 2006-10-10 |
A new bioactive prenylated dihydroflavanoid from Dolichos tenuicaulis (Baker) Craib |
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| Jin Yong Peng Hal Yan Liu Yan Qi Xu Han You Wei Xu Li Na Xu Qi Wei Xu.A new bioactive prenylated dihydroflavanoid from Dolichos tenuicaulis (Baker) Craib[J].Chinese Chemical Letters,2007,18(3):293-296. |
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| Authors: | Jin Yong Peng Hai Yan Liu Yan Qi Xu Han You Wei Xu Li Na Xu Qi Wei Xu |
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| Institution: | 1. School of Pharmacy, Dalian Medical University, Dalian 116027, China;2. People''s Hospital of the State of Xishuangbanna, Yunnan 666100, China |
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| Abstract: | A new prenylated dihydroflavonoid was obtained from the root of Dolichos tenuicaulis (Baker) Craib. The structure was elucidated as (2S)-5,2′,6′-trihydroxy-3″′, 8-di (γ, γ-dimethyl-allyl)-2″′, 2″′-dimethylpyrano-5″′,6″′: 6,7]-2″″′,4″″′-cyclohexadiene-1′″″-one-2′″″,3′″″: 3′,4′]-flavanone, named dolichnin A, by spectroscopic methods including UV, IR, HR-EI-MS, 1D NMR and 2D NMR techniques, and subsequently, the anticancer activity of this compound to inhibit human cancer cells’ growth including A549, BEL-7402, Hep-3B, SMMC7721, HT-29, MCF-7, SGC-7902, K562, A498 and PC3 cell lines by MTT method was evaluated in vitro. |
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| Keywords: | Dolichos tenuicaulis (Baker) Craib Prenylated dihydroflavonoid Anticancer activity |
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