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Improving resins for solid phase synthesis: incorporation of 1-[2-(2-methoxyethoxy)ethoxy]-4-vinyl-benzene |
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| Authors: | Sonia M AlessoZhanru Yu David PearsPaul A Worthington Richard WA LukeMark Bradley |
| Institution: | a Department of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK b Avecia, P.O. Box 42, Hexagon House, Blackley, Manchester M9 8ZS, UK c Syngenta, Jealott's Hill Research Station, Bracknell, Berkshire RG42 6EY, UK d AstraZeneca Pharmaceuticals, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK |
| Abstract: | The preparation, characterisation and application of a series of non-grafted polystyrene (PS) resins containing a styrenic methoxypoly(ethylene glycol) (MPEG) derivative is presented. These novel PS-MPEG resins were designed to balance swelling and solvation with improved handling. The monomer, 1-2-(2-methoxyethoxy)ethoxy]-4-vinyl-benzene, contained an inert phenyl ether linkage designed to provide broad chemical compatibility and stability, yet imparting all the favourable properties of the PEG group into the new resin, whilst maintaining a high loading capacity. The synthetic performance of the new resins compared very favourably to those of TentaGel™, ArgoGel™ and aminomethyl PS. |
| Keywords: | styrenic methoxypoly(ethylene glycol) (MPEG) monomer resins solid supports solid phase synthesis |
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