| 咪唑-金属配合物的合成、性质及其与DNA的作用机理 |
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| 引用本文： | 张书圣,牛淑妍,接贵芬,李雪梅,徐华,石昕,焦奎.咪唑-金属配合物的合成、性质及其与DNA的作用机理[J].中国化学,2006,24(1):51-58. |
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| 作者姓名： | 张书圣 牛淑妍 接贵芬 李雪梅 徐华 石昕 焦奎 |
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| 作者单位： | College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, Shandong 266042, China |
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| 基金项目： | Project supported by the Program for New Century Excellent Talents in University （No. NCET-04-0649） and the National Natural Science Foundation of China （Nos. 20275020, 20475030）. |
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| 摘 要： | Three hexakis（imidazole）metallo complexes of Co, Cd and Ni were synthesized and spectroscopically characterized. The crystal and molecular structures have been determined by X-ray crystallography analysis. The metal ions have an octahedral geometry with the MN6 chromophore. The electrochemical experimental results indicate that both Co（Im）6]C12·2HCl·2H2O （1） and Ni（Im）6]C12·4H2O （3） Im=imidazole] could interact with DNA mainly by intercalation.
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| 关 键 词： | 咪唑 晶体结构 电化学 合成方法 结构表征 X光线衍射 |
| 收稿时间： | 2005-01-12 |
| 修稿时间： | 2005-01-122005-09-05 |
Studies on the Synthesis of Imidazole-metal Complexes and Their Characterization and Binding Mechanism with DNA |
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| Zhang ShuSheng;Niu ShuYan;Jie GuiFen;Li XueMei;Xu Hua;Dan Xin;Jiao Kui.Studies on the Synthesis of Imidazole-metal Complexes and Their Characterization and Binding Mechanism with DNA[J].Chinese Journal of Chemistry,2006,24(1):51-58. |
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| Authors: | Zhang ShuSheng;Niu ShuYan;Jie GuiFen;Li XueMei;Xu Hua;Dan Xin;Jiao Kui |
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| Abstract: | Three hexakis(imidazole)metallo complexes of Co, Cd and Ni were synthesized and spectroscopically characterized. The crystal and molecular structures have been determined by X‐ray crystallography analysis. The metal ions have an octahedral geometry with the MN6 chromophore. The electrochemical experimental results indicate that both Co(Im)6]Cl2·2HCl·2H2O ( 1 ) and Ni(Im)6]Cl2·4H2O ( 3 ) Im?imidazole] could interact with DNA mainly by intercalation. |
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| Keywords: | imidazole complex salmon sperm DNA X-ray crystal structure electrochemical characteristic |
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