手性4-取代丁内酯类化合物的合成及其结构研究

脂肪族伯胺和伯醇作为亲核试剂5与5-L-孟氧基丁烯内醋（4）手性合成子通过 不对称Michael加成，得到代-丁内酯类化合物6（44％-57％，ee≥98％）．通过元 素分析，α]_D~(20)，IR，1~H NMR，了它们的化学结构、立体构型、绝对构型． 可以为某些具有生物活性的化合物及复杂分子的合成提供新的途径．

Studies on the Synthesis and Structure of Chiral 4-Substituted- butyrolactone Derivatives

The novel chiral compounds 6 have been synthesized in 44%-57% yields with ee ≥98% by asymmetric Michael addition of chiral synthon, 5-L-menthyloxy-butenolides (4) with aliphatic primary amine and primary alcohol 5 as nucleophilic reagents. The structure and absolute configuration were established on the basis of their elemental analysis and spectroscopic data, such as a]_D~(20), IR, 'H NMR, (13) ~C NMR, MS and X-ray crystallography. These results provide a valuable synthetic route to some complex molecules and biological active compounds.