Solid-phase synthesis of phenols and pyridinones via arylboronation/oxidation protocol using aryl bromides |
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Authors: | Younghee Lee Martha J Kelly |
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Institution: | Locus Pharmaceuticals, Inc., Four Valley Square, 512 Township Line Road, Blue Bell, PA 19422, USA |
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Abstract: | A sequence of two known reactions, palladium catalyzed arylboronation of arybromide and subsequent oxidation of arylboronate with oxone, has been carried out to prepare functionalized phenols and pyridin-2(1H)-one which were later loaded on to resin for solid-phase synthesis. Using these resin-bound templates, a number of solid-phase methods were developed to generate libraries of substituted phenols and pyridin-2(1H)-one. |
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Keywords: | Solid-phase synthesis Arylboronation Oxidation Phenol Pyridinone |
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