| 硅胶键合手性配体交换固定相键合量对α-氨基酸拆分的影响 |
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| 引用本文： | 祝馨怡,韩小茜,齐邦峰,李永民,蒋生祥,陈立仁.硅胶键合手性配体交换固定相键合量对α-氨基酸拆分的影响[J].色谱,2002,20(3):223-226. |
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| 作者姓名： | 祝馨怡 韩小茜 齐邦峰 李永民 蒋生祥 陈立仁 |
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| 作者单位： | 中国科学院兰州化学物理研究所,甘肃,兰州,730000 |
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| 基金项目： | 中国科学院重点基金资助项目 (批准号 :KY95 S1 2 0 5 ) |
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| 摘 要： | 合成了两种不同键合量的L 脯氨酸硅胶键合手性配体交换固定相 ,装柱后利用配体交换法分离了一系列的α 氨基酸。实验结果表明键合量不同的固定相对α 氨基酸的拆分能力差别较大。
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| 关 键 词： | 配体交换 L脯氨酸 手性固定相 对映体分离 键合量 α氨基酸 |
| 文章编号： | 1000-8713(2002)03-0223-04 |
| 修稿时间： | 2001年10月30 |
Effect of the Bonding Amounts of Chiral Ligand Exchange Chromatogr-aphic Stationary Phases on the Enantioseparation of Amino Acids |
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| ZHU Xin yi,HAN Xiao qian,QI Bang feng,LI Yong min,JIANG Sheng xiang,CHEN Li ren.Effect of the Bonding Amounts of Chiral Ligand Exchange Chromatogr-aphic Stationary Phases on the Enantioseparation of Amino Acids[J].Chinese Journal of Chromatography,2002,20(3):223-226. |
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| Authors: | ZHU Xin yi HAN Xiao qian QI Bang feng LI Yong min JIANG Sheng xiang CHEN Li ren |
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| Institution: | Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China. zxylz@yahoo.com |
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| Abstract: | L proline chiral stationary phases with various bonding amounts for ligand exchange chromatography were prepared by treating silica gel with 3 glycidoxypropyltrimethoxysilane and bonding L proline. The bonding amounts of L proline chiral stationary phase were controlled effectively and characterized by IR and elemental analysis. Some DL amino acids were separated and the influences of the bonding amounts on the efficiency of resolution of DL amino acids by ligand exchange chromatography were briefly discussed and explained by the mechanism of the separation. |
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| Keywords: | NULL |
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