Mechanistic considerations on contact-active antimicrobial surfaces with controlled functional group densities |
| |
Authors: | Bieser Arno M Tiller Joerg C |
| |
Institution: | Freiburg Material Research Center and Institute for Macromolecular Chemistry, Department of Chemistry, University of Freiburg, Stefan-Meier-Str. 21, D-79104 Freiburg, Germany. |
| |
Abstract: | A series of N-alkyl-N,N-dimethyldeoxyammonium celluloses is synthesized by converting tosyl celluloses with DBA and DDA, respectively. Surface coatings with these water-insoluble derivatives contain well-defined densities of quaternary ammonium functions and nonactive hydrophobic and hydrophilic groups. It is shown that the antimicrobial activity of such surfaces against S. aureus requires a delicate balance between DDA, BDA, and hydrophobic groups. A mechanism is proposed that involves the selective adhesion of anionic phospholipids from the bacterial cell membrane. This so-called phospholipid sponge effect is supported by the fact that all coatings could be deactivated by treatment with SDS or negatively charged phospholipids, but not with neutral phospholipids. |
| |
Keywords: | antimicrobial surfaces cellulose NMR phospholipids quaternary ammonium groups |
本文献已被 PubMed 等数据库收录! |
|