N-Sulfonyl acetylketenimine as a highly reactive intermediate for synthesis of N-Aroylsulfonamides |
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| Authors: | Weiguang Yang Dayun Huang Xiaobao Zeng Jianlan Zhang Xinyan Wang Yuefei Hu |
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| Institution: | Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, PR China |
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| Abstract: | A highly reactive intermediate N-sulfonyl acetylketenimine was generated from an ynone-participated CuAAC/ring-opening method. Its unique structure allowed it to react with aryl carboxylic acids to give N-aroylsulfonamides via a novel Mumm-type rearrangement. |
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| Keywords: | Copper Cyclization Click chemistry Amides Ketenimines |
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