卡替诺尔和氟西汀对映体的高效毛细管电泳分离

考察了以羧甲基－β－（环糊精－β－CD）、β－环糊清（β－CD）、羟丙基－β－环糊精（HP－β－CD）、二甲基－β－环糊精（DM－β－CD)为手性选择剂，在50mmol/L醋酸三乙胺缓冲溶液中分离卡替诺尔和氟西汀对映体。该文还通过考察手性选择剂的浓度、背景电解质的酸度、背景电解质的类型等因素对映体手性分离的影响，对分离条件进行了优化，初步探讨了手性识别机理。实验结果表明：用约4mmol/L的CM－β－CD分离氟西汀和卡替诺尔对映体，能使对映体达到良好分离，不仅节约了分析成本，也简化了分析过程。

Chiral Resolution of Fluoxetine and Carteolol by High Performance Capillary Electrophoresis

A method for separating enantiomers of fluoxetine and carteolol is described by HPCE using β _ cyclodextrin(β _ CD),carboxylmethyl _ β _ cyclodextrin(CM _ β _ CD),hydroxypropyl _ β _ cyclodextrin(HP_ β_ CD) and dimethyl _ β _ cyclodextrin(DM _ β _ CD) as a chiral selector.The separations were performed on an uncoated capillary of 50 cm× 75 μ m.The effects of types and concentrations of CDs in buffer on chiral resolution were investigated.The effects of pH and types of the background electrolytes on chiral resolution were also examined and separation conditions were optimized.It was observed that a good separation of carteolol or fluoxetine can be achieved by using approx 4 mmol/L of CM _ β _ CD,which not only saves analysis cost,but also simplifies the procedure.The mechanism of the chiral resolution was discussed briefly.