| Ming-Phos/Gold(Ⅰ)-Catalyzed Stereodivergent Synthesis of Highly Substituted Furo[3,4-d][i,2]oxazines |
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| 作者姓名： | Lujia Zhou Bing Xu Danting Ji Zhan-Ming Zhang Junliang Zhang |
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| 作者单位： | Shanghai Key Laboratory of Green Chemistry and Chemical Processes;Department of Chemistry |
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| 基金项目： | the fundi ng support of NSFC(Nos.21425205,21672067,21801078);973 Program(No.2015CB856600);the Program of Eastern Scholar at Shanghai Institutions of Higher Learning and the China Postdoctoral Science Foundation(Nos.2019M650071,2019M661418). |
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| 摘 要： | A gold(Ⅰ)-catalyzed asymmetric intermolecular tandem3+3]-cyclization reaction of 2-(l-alkynyl)-2-alken-l-ones with nitrones has been developed by using Ming-Phos as a chiral ligand.This method enables access to the stereodivergent synthesis of highly substituted furo3,4-d]l,2]oxazines in excellent efficiency and stereoselectivity(up to 99% yield,99% ee,>20:1 dr).
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| 关 键 词： | SUBSTITUTED HIGHLY |
Ming‐Phos/Gold(I)‐Catalyzed Stereodivergent Synthesis of Highly Substituted Furo[3,4‐d][1,2]oxazines† |
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| Lujia Zhou,Bing Xu,Danting Ji,Zhan-Ming Zhang,Junliang Zhang.
Ming‐Phos/Gold(I)‐Catalyzed Stereodivergent Synthesis of Highly Substituted Furo[3,4‐d][1,2]oxazines†[J].Chinese Journal of Chemistry,2020,38(6):577-582. |
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| Authors: | Lujia Zhou Bing Xu Danting Ji Zhan‐Ming Zhang Junliang Zhang |
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| Abstract: | A gold(I)‐catalyzed asymmetric intermolecular tandem 3+3]‐cyclization reaction of 2‐(1‐alkynyl)‐2‐ alken‐1‐ones with nitrones has been developed by using Ming‐Phos as a chiral ligand. This method enables access to the stereodivergent synthesis of highly substituted furo3,4‐d]1,2]oxazines in excellent efficiency and stereoselectivity (up to 99% yield, 99% ee, >20 : 1 dr). |
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| Keywords: | Gold Cycloaddition Asymmetric catalysis Phosphine ligands Stereodivergent synthesis 3 4‐Fused bicyclic furans |
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