Synthesis and Characterization of Far‐Red/NIR‐Fluorescent BODIPY Dyes,Solid‐State Fluorescence,and Application as Fluorescent Tags Attached to Carbon Nano‐onions |
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Authors: | Dr Juergen Bartelmess Dr Michele Baldrighi Dr Valentina Nardone Dr Emilio Parisini David Buck Prof?Dr Luis Echegoyen Prof?Dr Silvia Giordani |
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Institution: | 1. Istituto Italiano di Tecnologia (IIT), Nano Carbon Materials, Via Morego 30, 16163 Genova (Italy);2. Istituto Italiano di Tecnologia (IIT), Center for Nano Science and Technology, Via G. Pascoli 70/3, 20133 Milano (Italy);3. Department of Chemistry, Material and Chemical Engineering, Politecnico di Milano, Piazza Leonardo Da Vinci, 20133 Milano (Italy);4. Department of Chemistry, University of Texas at El Paso, 500 W. University Ave., El Paso, TX 79968 (USA) |
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Abstract: | A series of π‐extended distyryl‐substituted boron dipyrromethene (BODIPY) derivatives with intense far‐red/near‐infrared (NIR) fluorescence was synthesized and characterized, with a view to enhance the dye’s performance for fluorescence labeling. An enhanced brightness was achieved by the introduction of two methyl substituents in the meso positions on the phenyl group of the BODIPY molecule; these substituents resulted in increased structural rigidity. Solid‐state fluorescence was observed for one of the distyryl‐substituted BODIPY derivatives. The introduction of a terminal bromo substituent allows for the subsequent immobilization of the BODIPY fluorophore on the surface of carbon nano‐onions (CNOs), which leads to potential imaging agents for biological and biomedical applications. The far‐red/NIR‐fluorescent CNO nanoparticles were characterized by absorption, fluorescence, and Raman spectroscopies, as well as by thermogravimetric analysis, dynamic light scattering, high‐resolution transmission electron microscopy, and confocal microscopy. |
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Keywords: | carbon nanostructures fluorescent probes imaging agents solid‐state fluorescence |
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