| 基于环糊精手性选择剂的几种手性药物对映体的毛细管电泳拆分 |
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| 引用本文： | 郑志侠,汪家权,程红,肖莆.基于环糊精手性选择剂的几种手性药物对映体的毛细管电泳拆分[J].化学研究,2010,21(1):76-79. |
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| 作者姓名： | 郑志侠 汪家权 程红 肖莆 |
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| 作者单位： | 1. 安徽省环境科学研究院,安徽省污水处理技术重点实验室,安徽,合肥,230061
2. 合肥工业大学,资源与环境工程学院,安徽,合肥,230009 |
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| 基金项目： | 国家科技部国际科技合作项目，安徽省优秀青年科技基金 |
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| 摘 要： | 以环糊精(-αCD、-βCD和-γCD)为手性选择剂,采用毛细管电泳对扑尔敏、异丙嗪和二氧异丙嗪对映体进行了分离,考察了手性选择剂的浓度、缓冲液pH值及有机添加剂对手性分离的影响,并就拆分机理进行了初步探讨.
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| 关 键 词： | 手性药物对映体 扑尔敏 异丙嗪 二氧异丙嗪 环糊精 毛细管电泳 手性拆分 |
Enantioseparation of Several Pharmaceutical Enantiomers by Capillary Electrophoresis with Cyclodextrins as Chiral Selectors |
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| ZHENG Zhi-xia,WANG Jia-quan,CHENG Hong,XIAO Pu.Enantioseparation of Several Pharmaceutical Enantiomers by Capillary Electrophoresis with Cyclodextrins as Chiral Selectors[J].Chemical Research,2010,21(1):76-79. |
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| Authors: | ZHENG Zhi-xia WANG Jia-quan CHENG Hong XIAO Pu |
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| Institution: | 1. Anhui Provincial Academy of Environmental Science, Anhui Provincial Key Laboratory of Wastewater Treatment Technology, Hef ei 230061, Anhui, China; 2. School of Resources and Environment, Hefei University of Technology, Hefei 230091, Anhui, China) |
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| Abstract: | Cyclodextrin （a-CD, β-CD and γ-CD） were used as chiral selectors to separate chlor- pheniramine, promethazine and dioxopromethazine enantiomers via capillary electrophoresis. The effects of the concentration of chiral selectors, pH value of buffer solution and organic modifiers on the separation efficacy were investigated. Moreover, possible chiral separation mechanisms were briefly discussed. |
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| Keywords: | pharmaceutical enantiomer chlorpheniramine promethazine dioxopromethazine cyclodextrin capillary electrophoresis enantioseparation |
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