| 支链淀粉-三(苯基氨基甲酸酯)手性固定相的制备及对外消旋环酮和环醇的直接拆分 |
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| 引用本文： | 周志强,侯经国,蒋生祥,陈立仁.支链淀粉-三(苯基氨基甲酸酯)手性固定相的制备及对外消旋环酮和环醇的直接拆分[J].分析化学,1997(12). |
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| 作者姓名： | 周志强 侯经国 蒋生祥 陈立仁 |
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| 作者单位： | 中国科学院兰州化学物理研究所!兰州730000 |
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| 基金项目： | 中国科学院重点项目基金 |
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| 摘 要： | 在参照文献基础上，合成并制备了支链淀粉－三（苯基氨基甲酸酯）手性固定相，以此手性固定相为基础，利用高效液相色谱首次直接拆分了３种外消旋环酮和一种外消旋环醇，并考察了流动相中异丙醇含量对拆分的影响。
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| 关 键 词： | 高效液相色谱 支链淀粉-三(苯基氨基甲酸酯) 外消旋化合物 手性拆分 |
Direct Enantiomeric Resolution of Cyclic Ketones and Cyclic Alcohol Using Amylopectin Tris(Phenylcarbamate) Chiral Stationary Phase |
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| Zhou Zhiqiang,Hou Jingguo,Jiang Shengxiang,Chen Liren.Direct Enantiomeric Resolution of Cyclic Ketones and Cyclic Alcohol Using Amylopectin Tris(Phenylcarbamate) Chiral Stationary Phase[J].Chinese Journal of Analytical Chemistry,1997(12). |
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| Authors: | Zhou Zhiqiang Hou Jingguo Jiang Shengxiang Chen Liren |
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| Abstract: | In the present study, we have synthesized amylopectin tris(phenylcarbamate) and used it as chiral stationary phase. This stationary phase offers a practically useful chiral column with a high enantiomer-separability. Amylopectin was allowed to react with an excess of phenylisocyanate in pyridine for 48 h. The carbamates obtained was dissolved and adsorbed on silica gel which had been treated with 3-aminopropyltriethoxysilane. The weight ratio of the carbamate to the silica gel was 0. 45/2. 55. Three cyclic ketones and one cyclic alcohol were resolved on amylopectin tris(phenylcarbamate) chiral stationary phase with a he-cane/2-propanol mixture at a flow rate of 0. 5 mL/min at room temperature. The effects of 2-propanol concentration on the retention and resolution have been investigated. |
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| Keywords: | High performance liquid chromatography amylopectin tris (phenylcarbamate) cyclic ketone cyclic alcohol enantiomeric separation |
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