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具有生物活性的N-(1-二茂铁亚乙基氨基)-N'-β-D-吡喃糖基硫脲的合成与表征
引用本文:张书圣,杨波,李会香,焦奎.具有生物活性的N-(1-二茂铁亚乙基氨基)-N''-β-D-吡喃糖基硫脲的合成与表征[J].中国化学,2005,23(9):1253-1256.
作者姓名:张书圣  杨波  李会香  焦奎
作者单位:[1]College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, Shandong 266042, China
基金项目:Project supported by the Program for New Century Excellent Talents in University (No. NCET-04-0649) and the National Natural Science Foundation of China (Nos. 20275020, 20475030).
摘    要:Several novel N′-(1-ferrocenylethylidene)amino]-N′-β-D-glycopyranosylthioureas have been efficiently synthesized via a six-step procedure, utilizing three monosaccharides (D-glucose, D-galactose and D-xylose) as starting materials, respectively. They have been preliminarily determined to display biological activity against certain fungi. The target compounds have been unambiguously characterized by spectroscopic method and elemental analysis. An initially alternative synthetic route, which was seemingly reasonable, has been excluded due to its inefficiency.

关 键 词:糖酶  合成方法  生物活性  氨基酸
收稿时间:2004-09-09
修稿时间:2004-09-092005-05-08

Facile Synthesis and Characterization of Bioactive N‐[(1‐Ferrocenylethylidene)amino]‐ N′ ‐β‐D‐glycopyranosylthiourea
ZHANG Shu-Sheng,YANG Bo,LI Hui-Xiang, JIAO Kui.Facile Synthesis and Characterization of Bioactive N‐[(1‐Ferrocenylethylidene)amino]‐ N′ ‐β‐D‐glycopyranosylthiourea[J].Chinese Journal of Chemistry,2005,23(9):1253-1256.
Authors:ZHANG Shu-Sheng  YANG Bo  LI Hui-Xiang  JIAO Kui
Abstract:Several novel N‐(1‐ferrocenylethylidene)amino]‐NβD‐glycopyranosylthioureas have been efficiently synthesized via a six‐step procedure, utilizing three monosaccharides (D‐glucose, D‐galactose and D‐xylose) as starting materials, respectively. They have been preliminarily determined to display biological activity against certain fungi. The target compounds have been unambiguously characterized by spectroscopic method and elemental analysis. An initially alternative synthetic route, which was seemingly reasonable, has been excluded due to its inefficiency.
Keywords:thiourea  saccharide  ferrocene  synthesis  bioactivity
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