|
|||||
|
|
Copper-Catalyzed C(sp3)-Amination of Ketone-Derived Dihydroquinazolinones by Aromatization-Driven C−C Bond Scission |
|
| Authors: | Xin-Yang Lv Roman Abrams Prof Ruben Martin |
| Institution: | 1. Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Spain
Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, c/Marcel⋅lí Domingo, 1, 43007 Tarragona, Spain;2. Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Spain |
| Abstract: | Herein, we describe the development of a copper-catalyzed C(sp3)-amination of proaromatic dihydroquinazolinones derived from ketones. The reaction is enabled by the intermediacy of open-shell species arising from homolytic C−C bond-cleavage driven by aromatization. The protocol is characterized by its operational simplicity and generality, including chemical diversification of advanced intermediates. |
| Keywords: | Amination C−C Functionalization Copper Ketones Proaromaticity |