Ultrasensitive and Simple Method for Determination of N‐Acetyl‐L‐Cysteine in Drug Formulations Using a Diamond Sensor |
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| Authors: | Siriwan Nantaphol Orawon Chailapakul Weena Siangproh |
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| Institution: | 1. Electrochemistry and Optical Spectroscopy Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Phyathai Rd. Patumwan, Bangkok, 10330, Thailand;2. Department of Chemistry, Faculty of Science, Srinakharinwirot University, Sukhuvit 23 Rd. Wattana, Bangkok, 10110, Thailand |
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| Abstract: | A boron‐doped diamond (BDD) electrode coupled to flow injection analysis (FIA) was firstly developed for determination of N‐acetyl‐L ‐cysteine (NAC) in drug formulations. The effects of experimental parameters including pH, applied potential and scan rate on the response were investigated. FIA amperometry was applied as an automatic method for the quantitative detection of trace amounts of NAC. A wide linear range of 0.5–50 µmol/L and a low detection limit of 10 nmol/L were obtained. The results of amperometric determinations show a very good reproducibility, and the RSD for the measurement based on 10 measurements was <3.7 % and <4.1 % for intra‐ and inter‐day, respectively. The benefits of the proposed method are fast, simple, sensitive and no requirement of complicated operational steps. |
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| Keywords: | N‐Acetyl‐L‐cysteine Boron‐dope diamond sensor Flow injection analysis Drug formulations Amperometry |
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