Fluoxetine Hydrochloride的NMR数据解析

由美国Lilly公司开发的第二代抗抑郁症药物盐酸氟西汀（Fluoxetine hydrochloride），属于选择性5-羟色胺再摄取抑制剂（SSRI），除了用于治疗各类抑郁症，包括轻性或重性抑郁症，尤宜用于老年性抑郁症之外，对于强迫症、惊恐发作、贪食症、经前期焦虑等亦有很好疗效. Fluoxetine hydrochloride是一种双环化合物，与传统的三环类、杂环类或单胺氧化酶抑制剂抗抑郁药相比，具有疗效好、不良反应轻而少，安全性高、耐受性好等特点，目前已作为一线的抗抑郁药得到广泛应用. 本文对Fluoxetine hydrochloride进行了¹H NMR和¹³C NMR检测，并通过DEPT和¹H-¹H COSY、HMBC、HSQC等2D NMR技术对其¹H NMR和¹³C NMR数据进行了较为详细的解析和比文献1]更为全面的NMR归属，为以后的分析鉴定提供更完善的依据.

NMR Study of Fluoxetine Hydrochloride

Fluoxetine hydrochloride is a novel type of antidepressant that was developed by Eli Lilly and other companies in the United States. It has been used as a first line drug in clinical practice for treating depression, especially gerontal depression. In addition, the compound is also used for treatments of anxiety, chronic pain and eating disorders such as obesity and bulimia. Compared to the traditional tricyclic antidepressants, fluoxetine also exhibits tolerability and safety aevantages. The chemical structure of fluoxetine hydrochloride is a bicyclic compound belonging to a class of selective serotonin reuptake inhibitors. In this study, the 1H and 13C NMR spectra of fluoxetine were acquired, completely assigned and analyzed by a combination of 1D (1H, 13C NMR and DEPT) and 2D NMR (1H-1H COSY, HSQC and HMBC) techniques. The results obtained in this study will provide a reference for characterization of similar compounds in the future.