Electrosprayed droplet impact/secondary ion mass spectrometry |
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Authors: | K Hiraoka D Asakawa S Fujimaki A Takamizawa K Mori |
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Institution: | (1) Clean Energy Research Center, University of Yamanashi, Takeda-4, Kofu 400-8511, Japan |
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Abstract: | A new ionization method, electrosprayed droplet impact ionization (EDI), has
been developed for mass spectrometry. The charged droplets formed by
electrospraying 1 M acetic acid aqueous solution are sampled through an
orifice with a diameter of 400 μm into the first vacuum chamber,
transported into a quadrupole ion guide and accelerated by 10 kV after
exiting the ion guide. The m/z of the primary droplet projectiles range from
10 000 to 50 000. The droplets impact on a dry solid sample deposited on a
stainless steel substrate. No matrix was used for the sample preparation.
The secondary ions formed by the impact are transported to a second
quadrupole ion guide and mass-analyzed by an orthogonal TOF-MS. Intense
molecular-related ions are detected for drugs, amino acids, peptides and
proteins. EDI is found to be very sensitive to molecules present near the
surface of the sample. |
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Keywords: | 34 50 Dy Interactions of atoms and molecules with surfaces photon and electron emission neutralization of ions 36 40 Gk Plasma and collective effects in clusters 39 10 +j Atomic and molecular beam sources and techniques |
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