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Although recent decades have witnessed the synthesis of 1,3,4-thiadiazoles via phosphorus POCl3-promoted cyclization reaction, simultaneous access to 2-amino-1,3,4-thiadiazole and 2-amino-1,3,4-oxadiazole analogs remains unexpected and elusive. Herein, a detailed regiocontrolled synthesis of 2-amino-1,3,4-thiadiazoles in good to high yields with good regioselectivities from readily available thiosemicarbazides using POCl3 was disclosed. Meantime, to establish a comprehensive structure–activity relationship, 2-amino-1,3,4-oxadiazole derivatives as single regioisomers were prepared via EDCI·HCl-triggered cyclization of the thiosemicarbazide intermediates. The in vitro anti-influenza assays proved that the selected compounds with the pyrazine/pyridine ring exhibited certain inhibitory activities against influenza A virus strains A/HK/68 (H3N2) and A/PR/8/34 (H1N1) in MDCK cells. Among them, N-(adamantan-1-yl)-5-(5-(azepan-1-yl)pyrazin-2-yl)-1,3,4-thiadiazol-2-amine (4j) was the most active compound, and exhibited favorable activity with EC50 values of 3.5 μM and 7.5 μM, respectively. In addition, the molecular docking results explained the reason why compound 4j had dual inhibitory activity and revealed the reasonable binding mode of this compound with the M2-S31N and M2-WT ion channels. This compound had the potential to be further developed as an anti-influenza drug.  相似文献   
3.
The rank of a graph is defined to be the rank of its adjacency matrix. A graph is called reduced if it has no isolated vertices and no two vertices with the same set of neighbors. We determine the maximum order of reduced triangle‐free graphs with a given rank and characterize all such graphs achieving the maximum order.  相似文献   
4.
We formulate a definition of isometric action of a compact quantum group (CQG) on a compact metric space, generalizing Banica's definition for finite metric spaces. For metric spaces (X,d)(X,d) which can be isometrically embedded in some Euclidean space, we prove the existence of a universal object in the category of the compact quantum groups acting isometrically on (X,d)(X,d). In fact, our existence theorem applies to a larger class, namely for any compact metric space (X,d)(X,d) which admits a one-to-one continuous map f:X→Rnf:XRn for some n   such that d0(f(x),f(y))=?(d(x,y))d0(f(x),f(y))=?(d(x,y)) (where d0d0 is the Euclidean metric) for some homeomorphism ?   of R+R+.  相似文献   
5.
Phase field models recently gained a lot of interest in the context of tumour growth models. Typically Darcy-type flow models are coupled to Cahn–Hilliard equations. However, often Stokes or Brinkman flows are more appropriate flow models. We introduce and mathematically analyse a new Cahn–Hilliard–Brinkman model for tumour growth allowing for chemotaxis. Outflow boundary conditions are considered in order not to influence tumour growth by artificial boundary conditions. Existence of global-in-time weak solutions is shown in a very general setting.  相似文献   
6.
A non-nilpotent variety of algebras is almost nilpotent if any proper subvariety is nilpotent. Let the base field be of characteristic zero. It has been shown that for associative or Lie algebras only one such variety exists. Here we present infinite families of such varieties. More precisely we shall prove the existence of1) a countable family of almost nilpotent varieties of at most linear growth and2) an uncountable family of almost nilpotent varieties of at most quadratic growth.  相似文献   
7.
In this paper, we consider systems of fractional Laplacian equations in Rnwith nonlinear terms satisfying some quite general structural conditions. These systems were categorized critical and subcritical cases. We show that there is no positive solution in the subcritical cases, and we classify all positive solutions ui in the critical cases by using a direct method of moving planes introduced in Chen-Li-Li [11] and some new maximum principles in Li-Wu-Xu [27].  相似文献   
8.
Two criteria are given for a ring to have a left Noetherian left quotient ring (to find a criterion was an open problem since 70's). It is proved that each such ring has only finitely many maximal left denominator sets.  相似文献   
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10.
Seven new copper(II) complexes of type [Cu(A)(L)]?H2O (A = sparfloxacin, ciprofloxacin, levofloxacin, gatifloxacin, pefloxacin, ofloxacin, norfloxacin; L = 5‐[(3‐chlorophenyl)diazenyl]‐4‐hydroxy‐1,3‐thiazole‐2(3H)‐thione) were synthesized and characterized using elemental and thermogravimetric analyses, and electronic, electron paramagnetic resonance (EPR), Fourier transform infrared and liquid chromatography–mass spectroscopies. Tetrahedral geometry around copper is assigned in all complexes using EPR and electronic spectral analyses. All complexes were investigated for their interaction with herring sperm DNA utilizing absorption titration (Kb = 1.27–3.13 × 105 M?1) and hydrodynamic volume measurement studies. The studies suggest the classical intercalative mode of DNA binding. The cleavage reaction on pUC19 DNA was monitored by agarose gel electrophoresis. The results indicate that the Cu(II) complexes can more effectively promote the cleavage of plasmid DNA. The superoxide dismutase mimic activity of the complexes was evaluated by nitroblue tetrazolium assay, and the complexes catalysed the dismutation of superoxide at pH = 7.8 with IC50 values in the range 0.597–0.900 μM. The complexes were screened for their in vitro antibacterial activity against five pathogenic bacteria. All the complexes are good cytotoxic agents and show LC50 values ranging from 5.559 to 11.912 µg ml?1. All newly synthesized Cu(II) complexes were also evaluated for their in vitro antimalarial activity against Plasmodium falciparum strain (IC50 = 0.62–2.0 µg ml?1). Copyright © 2015 John Wiley & Sons, Ltd.  相似文献   
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