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| 纳米结构分子印迹聚合物及其在药物分析中的应用进展 | |
| 引用本文： | 李洁,刘铁兵,肖得力,Dramou Pierre,邹雯月,何华.纳米结构分子印迹聚合物及其在药物分析中的应用进展[J].分析化学,2012,40(9):1461-1468. |
| 作者姓名： | 李洁 刘铁兵 肖得力 Dramou Pierre 邹雯月 何华 |
| 作者单位： | 1. 中国药科大学分析化学教研室,南京,210009 2. 浙江科技学院中德农产品加工工业研究院,杭州,310023 3. 中国药科大学分析化学教研室,南京210009;药物质量与安全预警教育部重点实验室,南京210009 |
| 基金项目： | “新药创制”重大专项(No.2009ZX09301-006);浙江省自然科学基金项目(No.Y4110235);江苏省普通高校研究生科研创新计划基金(Nos.CXZZ11_0812)资助项目 |
| 摘 要： | 纳米材料是纳米技术发展的重要基础,它具有许多传统材料所不具备的独特的理化性质,因此有着广泛的应用前景.分子印迹技术是一种通过模拟抗体-抗原相互作用原理,制备具有分子识别功能的聚合物的技术.以纳米材料制备的分子印迹聚合物具有较高的结合容量,较大的选择性和较快的结合动力学特性,近年来备受关注.本文简单概述了零维、一维、二维纳米结构分子印迹聚合物的合成、表征方法及研究现状,并对其在手性药物分析、临床药物分析、传感器及药物残留检测中的应用进行了综述. |
| 关 键 词： | 分子印迹聚合物 纳米结构 药物分析 综述 |
Research and Application of Nanostructured Molecularly Imprinted Polymers in Pharmaceutical Analysis |
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| LI Jie , LIU Tie-Bing , XIAO De-Li , DRAMOU Pierre , ZOU Wen-Yue , HE Hua.Research and Application of Nanostructured Molecularly Imprinted Polymers in Pharmaceutical Analysis[J].Chinese Journal of Analytical Chemistry,2012,40(9):1461-1468. | |
| Authors: | LI Jie LIU Tie-Bing XIAO De-Li DRAMOU Pierre ZOU Wen-Yue HE Hua |
| Institution: | 1,3 1(Department of Analytical Chemistry,China Pharmaceutical University,Nanjing 210009,China) 2(The Sino-Germany Institute of Agriculture Products Processing Industry, Zhejiang University of Science and Technology,Hangzhou 310023,China) 3(Key Laboratory of Drug Quality Control and Pharmacovigilance,China Pharmaceutical University, Ministry of Education,Nanjing 210009,China) |
| Abstract: | Nanotechnology is an emerging technology with enormous potential due to their specific structures and properties that differ from traditional materials.Molecularly imprinting is a technique for the preparation of polymers of predetermined specificity based on imitating the way of interaction between antigen and antibody.Compared to conventional molecularly imprinted polymer,nanostructured molecularly imprinted polymer has many advantages: high afinity and selectivity,more accessible sites,fast association kinetics.Thus,nanostructured molecularly imprinting technique receives more and more attention by scientific researchers in recent years.This review covers the synthesis,characterization and latest advances of zero-dimensional(0-D),one-dimensional(1-D) and second-dimensional(2-D) nanostructured molecularly imprinted polymer.Moreover,the application of nanostructured molecularly imprinted polymer in the fields of chiral separation,clinical pharmaceutical analysis,sensor technology and drug residue detection were reviewed. |
| Keywords: | Molecularly imprinted polymers Nanostructure Pharmaceutical analysis Review |
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