Multiple-scattering speckle in holographic optical coherence imaging |
| |
| Authors: | K Jeong J J Turek M R Melloch and D D Nolte |
| |
| Institution: | (1) Department of Physics and Chemistry, Korea Military Academy, Seoul, 139-799, South Korea;(2) Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907, USA;(3) School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA;(4) Department of Physics, Purdue University, West Lafayette, IN 47907-2036, USA |
| |
| Abstract: | We investigate the effect of multiple scattering on the image quality of holographic optical coherence imaging, which is a
full-field coherence-domain imaging form of optical coherence tomography. The speckle holograms from turbid media and from
multicellular tumor spheroids are characterized by high-contrast speckle on a multiply-scattered background caused by channel
cross-talk. We quantify the multiple-scattered light that is accepted by the holographic coherence gate, and identify a cross-over
from single-scattered to multiple-scattered light beyond 15 to 20 optical thicknesses. Speckle reduction relies on vibrating
diffusers and on fast adaptive holograms in photorefractive quantum well devices. The high anisotropy factor for tumor tissue
reduces multiply-scattered light contributions for biomedical tumor imaging. |
| |
| Keywords: | PACS" target="_blank">PACS 42 30 Wb 42 30 Ms 42 40 My |
| 本文献已被 SpringerLink 等数据库收录！ |
|
