Mechanism of oxidation of diazepam by 1-chlorobenzotriazole in acidic medium. A kinetic approach |
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Authors: | N Nanda B S Sheshadri and S M Mayanna |
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Institution: | (1) Department of Chemistry, Central College, Bangalore University, 560 001 Bangalore, India |
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Abstract: | The kinetics of oxidation of diazepam (DZ) by 1-chlorobenzotriazole (CBT) has been studied in HClO4 medium in the temperature range of 293–323 K. The reactions followed a first order dependence on CBT], fractional order
each in H+] and DZ]. Activation parameters were evaluated. A negative entropy of activation indicated the involvement of a rigid complex
in the activated state. Variation of reaction rate with dielectric constant and the ionic strength are consistent with a mechanism
involving the decomposition of a dipole in the rate-determining step. Rate equation is derived to account for the observed
kinetic data and the proposed reaction mechanism. |
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Keywords: | Kinetics of oxidation diazepam 1-chlorobenzotriazole |
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