Preparation and characterization of biodegradable magnetic carriers by single emulsion-solvent evaporation |
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| Authors: | Xianqiao Liu Michael D Kaminski Judy S Riffle Haitao Chen Michael Torno Martha R Finck LaToyia Taylor Axel J Rosengart |
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| Institution: | 1. Departments of Neurology and Surgery (Neurosurgery), The University of Chicago Pritzker School of Medicine, Chicago, IL, USA;2. Chemical Engineering Division, Argonne National Laboratory, Argonne, IL, USA;3. Department of Chemistry, Virginia Tech, Blacksburg, VA, USA |
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| Abstract: | This paper describes a single emulsion-solvent evaporation protocol to prepare PEGylated biodegradable/biocompatible magnetic carriers by utilizing hydrophobic magnetite and a mixture of poly(D,L lactide-co-glycolide) (PLGA) and poly(lactic acid-block-polyethylene glycol) (PLA-PEG) (26:1 by mass) polymers. We characterized the magnetic microspheres in terms of morphology, composite microstructure, size and size distribution, and magnetic properties. Results show that the preparation produces magnetic microspheres with a good spherical morphology, small size (mean diameter of 1.2–1.5 μm) by means of large size distributions, and magnetizations up to 20–30 emu/g of microspheres. |
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| Keywords: | Magnetic carrier Biodegradable Magnetic target drug delivery Magnetite |
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