Amperometric Determination of Cholesterol-Reducing Drug,Ezetimibe, Using Glassy Carbon Electrode Modified with Multiwalled Carbon Nanotubes and Sodium Dodecylsulfate |
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Abstract: | A simple and sensitive electrochemical method is described for the determination of the cholesterol-reducing drug ezetimibe in aqueous solution. A glassy carbon electrode, modified with multiwalled carbon nanotubes and sodium dodecylsulphate was used as the working electrode. Ezetimibe yields a well-defined anodic peak at the surface of the electrode in an aqueous solution of pH 13. A linear amperometric calibration curve was obtained in the range of 1.2–78 μM (0.5–32.0 μg/mL) of ezetimibe, with a sensitivity of 88.6 nA/μM and a detection limit of 300 nM (0.12 μg/mL). The sensor was applied successfully to the determination of ezetimibe in pharmaceutical preparations. |
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Keywords: | Amperometry Determination Ezetimibe Modified electrode Multiwalled carbon nanotube Sodium dodecylsulphate |
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