| Enantiomer separation by CEC——Enantiomer separation by packed-capillary electrochromatography |
| |
| 引用本文： | 朱军
,邹汉法
,施维
,芮建中
,倪坚毅
,张玉奎.Enantiomer separation by CEC——Enantiomer separation by packed-capillary electrochromatography[J].中国科学B辑(英文版),1999(5). |
| |
| 作者姓名： | 朱军 邹汉法 施维 芮建中 倪坚毅 张玉奎 |
| |
| 基金项目： | Project supported by the Natural Science Foundation of Liaoning Province，China, the National Natural Science Foundation of China (Grant No. 29875030)，the Excellent Young Scientist Award from the National Natural Science Foundation of China. (Grant |
| |
| 摘 要： | Three chiral compounds were successfully separated in a short time with two enantiomer separation models on packed-capillary electrochromatography (CEC). (i) 75 μm I.D. capillaries were packed with 5 μm β-cyclodextrin (β-CD) chiral stationary phase (CSP). Effects of voltage, pH and concentration of organic modifier on electroosmotic flow (EOF) and chiral separations were investigated systematically. Enantiomers of a neutral compound (benzoin) and a neutral drug (mephenytoin) were separated within a short time with high efficiency. Efficiency of 32 000 theoretical plates per meter and resolution (R_s) of 1.42 were achieved for enantiomers of benzoin using a βCD packed column with 6.2 cm packed length. Efficiency of 45 000 theoretical plates per meter and R_s of 3.40 were obtained for enantiomers of mephenytoin. Especially, the enantiomer separation of mephenytion was performed in just 3.4 min with R_s of 2.60. (ⅱ) 75 μm I.D. capillary was packed with octadecylsilica particles (ODS). Chiral separat
|
Enantiomer separation by CEC-Enantiomer separation by packed-capillary electrochromatography |
| |
| ZHU Jun,ZOU Hanfa,SHI Wei
RUI Jianzhong,NI Jianyi and ZHANG Yukui.Enantiomer separation by CEC-Enantiomer separation by packed-capillary electrochromatography[J].Science in China(Chemistry),1999(5). |
| |
| Authors: | ZHU Jun ZOU Hanfa SHI Wei
RUI Jianzhong NI Jianyi and ZHANG Yukui |
| |
| Abstract: | |
| |
| Keywords: | packed-capillary electrochromatography enantiomer separation chiral selector fast analysis high efficiency resolution |
|
