|
|||||
|
|
Copper-catalyzed rearrangement of oximes into primary amides |
|
| Authors: | Sumeet K Sharma Simon D BishoppC Liana Allen Ruth LawrenceMark J Bamford Alexei A LapkinPawel Plucinski Robert J WatsonJonathan MJ Williams |
| Institution: | a Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK b GlaxoSmithKline Research and Development, Gunnels Wood Road, Stevenage SG1 2NY, UK c School of Engineering, University of Warwick, Coventry CV4 7AL, UK d Department of Chemical Engineering, University of Bath, Claverton Down, Bath BA2 7AY, UK |
| Abstract: | The atom-efficient and cost-effective rearrangement of oximes into primary amides is catalyzed by simple copper salts. The use of homogeneous Cu(OAc)2 (1-2 mol %) was found to be effective for this transformation at 80 °C. The reaction was successful with either conventional or microwave heating. CuO and CuO/ZnO on activated carbon provided a competent reuseable heterogeneous catalyst which could be used in a batch process or in flow. Copper salts are much cheaper than the precious metals previously used for this rearrangement, and the reaction conditions are milder than those reported. |
| Keywords: | Amide Copper Rearrangement Sustainable chemistry Synthetic methods |
| 本文献已被 ScienceDirect 等数据库收录！ | |