| Comparative molecular field analysis (CoMFA) of new herbicidal sulfonylurea compounds |
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| 作者姓名： | 刘洁 李正名 王霞 马翼 赖城明 贾国锋 王玲秀 |
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| 作者单位： | Elemento\|Organic Chemistry Institute，State Key Laboratory of Elemento\|Organic Chemistry，Nankai University，Tianjin 300071，China |
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| 基金项目： | ProjectsupportedbytheNationalNaturalScienceFoundationofChina (GrantedNo .2 9772 6 79)andtheStateKeyLabora toryofElemento OrganicChemistry |
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| 摘 要： | Ｓｕｌｆｏｎｙｌｕｒｅａｈｅｒｂｉｃｉｄｅｓｈａｖｅｂｅｅｎｕｓｅｄｆｏｒｓｅｖｅｒａｌｄｅｃａｄｅｓ,ｗｈｉｃｈｐｏｓｓｅｓｓｕｌｔｒａｌｏｗｄｏｓａｇｅ,ｌｏｗｍａｍｍａｌｉａｎｔｏｘｉｃｉｔｙａｎｄｄｅｓｉｒａｂｌｅｅｎｖｉｒｏｎｍｅｎｔａｌｐｒｏｐｅｒｔｉｅｓ.ＴｈｅｙｋｉｌｌｗｅｅｄｓｂｙｉｎｈｉｂｉｔｉｎｇｔｈｅａｃｔｉｖｉｔｙｏｆＡＬＳｅｎｚｙｍｅｏｆｔｈｅｗｅｅｄｓａｎｄｄｅｓｔｒｏｙｉｎｇｔｈｅｓｙｎｔｈｅｓｉｓｏｆｂｒａｎｃｈｃｈａｉｎａｍｉｎｏａｃｉｄ.Ｓｉｎｃｅｔｈｅｅｓｔａ…
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| 收稿时间： | 11 June 1997 |
Comparative molecular field analysis (CoMFA) of new herbicidal sulfonylurea compounds |
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| Jie Liu,Zhengming Li,Xia Wang,Yi Ma,Chengming Lai,Guofeng Jia,Lingxiu Wang.Comparative molecular field analysis (CoMFA) of new herbicidal sulfonylurea compounds[J].Science in China(Chemistry),1998,41(1):50-53. |
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| Authors: | Jie Liu Zhengming Li Xia Wang Yi Ma Chengming Lai Guofeng Jia Lingxiu Wang |
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| Institution: | (1) Elemento-Organic Chemistry Institute, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, 300071 Tianjin, China |
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| Abstract: | A series of new herbicidal sulfonylurea compounds were investigated aiming at developing a three dimensional quantitative structure activity relationship (3D QSAR) model using the CoMFA technique. On this base, some molecular structures were modified to improve their activities. A model of the target acetolactate syntheses (ALS) enzyme was established for the first time, which is useful to design and synthesis of new ALS enzyme inhibitor. |
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| Keywords: | CoMFA 3D QSAR ALS enzyme herbicidal sulfonylurea |
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