Gd2O3:Eu@mSiO2核壳双功能纳米棒的制备及性质

通过水热法和正硅酸乙酯水解法制备了一种新颖的Gd2O3:Eu@mSiO2核壳双功能(荧光和介孔)纳米棒。用扫描电镜(SEM)、透射电镜(TEM)、X射线粉末衍射(XRD)、红外光谱(FTIR)等多种测试手段对样品的形貌、物相结构进行分析表征。结果表明,该核壳结构纳米材料以Gd2O3:Eu纳米棒(长~400 nm,直径~100 nm)为核,介孔SiO2为壳,尺寸均匀,分散性良好。荧光光谱表明,在紫外光激发下,核壳纳米棒发射强烈的橙红色荧光。同时该核壳纳米棒能成功标记NCI-H460肺癌细胞。以布洛芬(IBU)为药物模型研究核壳纳米棒的药物负载和释放行为,结果表明,Gd2O3:Eu@mSiO2核壳纳米棒对IBU的负载量可达10.25%,而且其具有明显的缓释效果。IBU负载的样品(IBU-Gd2O3:Eu3+@mSiO2)在紫外光照射下仍呈现Eu3+的橙红色发光,且Eu3+在载药系统中的发光强度随IBU释放量的变化而变化,因此通过发光强度的变化可以跟踪和监测药物及其释放情况。

Synthesis and Properties of Bifunctional Gd2O3:Eu@mSiO2 Core-Shell Naonorods

A novel Gd₂O₃:Eu@mSiO₂ core-shell bifunctional nanorods were prepared by hydrothermal and tetraethyl orthosilicate hydrolysis methods. The morphology and phase structure of the samples were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray powder diffraction (XRD), infrared spectroscopy (FTIR). The results shows that the core-shell nanomaterial was composed of Gd₂O₃:Eu nanorods (length ~400 nm, diameter ~100 nm) as the core and mesoporous SiO₂ as the shell, and had uniform size and good dispersion. And the core-shell structured nanorod obtained strong red luminescence, giving the function of cell imaging upon incubation with the NCI-H460 lung cancer cells. The drug loading capacity and releasing behavior of the as-prepared Gd₂O₃:Eu@mSiO₂ were studied by using ibuprofen (IBU) as model drug. The results show that the IBU loading capacity of the Gd₂O₃:Eu@mSiO₂ core-shell nanorods could reach 10.25%, and the core-shell nanorods had obvious slow-release effect. Furthermore, IBU-loaded Gd₂O₃:Eu@mSiO₂ core-shell nanorod still showed red luminescence of Eu³⁺ under UV irradiation, and the emission intensity of Eu³⁺ in the drug-carrier system varied with the released amount of IBU, so that the drug together with its release situation can be easily tracked and monitored by the change in luminescence intensity.