Synthesis and properties of amphiphilic and biodegradable poly(ε‐caprolactone‐co‐glycidol) copolymers |
| |
| Authors: | Jinbao Xu Jinxian Yang Xiaodong Ye Chunfeng Ma Guangzhao Zhang Stergios Pispas |
| |
| Institution: | 1. Faculty of Materials Science and Engineering, South China University of Technology, Guangzhou, People's Republic of China;2. Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemical Physics, University of Science and Technology of China, Hefei, People's Republic of China;3. Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, Athens, Greece |
| |
| Abstract: | We have synthesized poly(ε‐caprolactone‐co‐tert‐butyl glycidyl ether) (CL‐co‐BGE) statistical copolymers using 1‐tert‐butyl‐4,4,4‐tris(dimethylamino)‐2,2‐bis tris(dimethylamino)phophoranylidenamino]‐2Λ5,4Λ5‐catenadi(phosphazene) (t‐BuP4) as the catalyst. The hydrolysis of the resulting polymers yields amphiphilic poly(ε‐caprolactone‐co‐glycidol) (CL‐co‐GD) copolymers. By use of the quartz crystal microbalance with dissipation (QCM‐D), we have investigated the enzymatic degradation of the copolymers. It is shown that the degradation rate increases with the content of hydrophilic (GD) units. (3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide) (MTT) assay experiments demonstrate that the CL‐co‐GD copolymers have low cytotoxicity. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015 , 53, 846–853 |
| |
| Keywords: | amphiphiles biodegradable enzymatic degradation polyesters poly(ε ‐caprolactone) QCM‐D ring‐opening polymerization t‐BuP4 |
|
|
