| 分子内环加成的甾体全合成 |
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| 引用本文： | 庄治平,周维善.分子内环加成的甾体全合成[J].有机化学,1983,3(6):405-416. |
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| 作者姓名： | 庄治平 周维善 |
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| 作者单位： | 中国科学院上海有机化学研究所，中国科学院上海有机化学研究所 |
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| 摘 要： | 近年来,分子内环加成反应已广泛用于甾体化合物全合成,其主要一步是由取代的苯并环丁烯热裂而成的5,6-二亚甲基-1,3-环己二烯发生区域专一和立体选择性的环加成反应,构成甾体骨架。现在用此法已合成了一系列消旋和光学活性的甾体化合物。
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| 关 键 词： | 综述 甾族化合物 立体选择性 旋光性 稠环化合物 苯(P) 环丁烯(P) 环加成反应 |
Total Synthesis of Steroids through Intramolecular Cycloaddition |
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| Zhuang Zhiping,Zhou Weishan.Total Synthesis of Steroids through Intramolecular Cycloaddition[J].Chinese Journal of Organic Chemistry,1983,3(6):405-416. |
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| Authors: | Zhuang Zhiping Zhou Weishan |
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| Institution: | Zhuang Zhiping,Zhou Weishan Shanghai Institute of Organic Chemistry,Academia Sinica |
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| Abstract: | This paper reviews the recent developments in intramolecular cycloadditionreaction widely used in total synthesis of steroidal compounds.The key step of this meth-od is regiospecific and stereoselective cycloaddition of substituted o-quinodimethanes de-rived in situ from the corresponding benzocyclobutenes. A large number of estrane and pregnane type steroids as well as optically active ster-oids have been synthesized by this method recently. |
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| Keywords: | review steroids stereoselectivity optical rotation fused ring compounds benzene(P) cyclobutene(P) cycloaddition reaction |
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