| Synthesis,DNA-binding,and Photocleavage of 2,3-Di-2-pyridylquinoxaline-silver（I） Complex |
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| 作者姓名： | WANG Xiu-li FANG Jia-ni BI Yan-feng LIN Hong-yan LIU Guo-cheng |
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| 作者单位： | WANG Xiu-li（Faculty of Chemistry and Chemical Engineering, Liaoning Key Laboratry of Applied Chemistry,Bohai University, Jinzhou 121000, P. R. China） ;
FANG Jia-ni（Faculty of Chemistry and Chemical Engineering, Liaoning Key Laboratry of Applied Chemistry,Bohai University, Jinzhou 121000, P. R. China） ;
BI Yan-feng（Faculty of Chemistry and Chemical Engineering, Liaoning Key Laboratry of Applied Chemistry,Bohai University, Jinzhou 121000, P. R. China） ;
LIN Hong-yan（Faculty of Chemistry and Chemical Engineering, Liaoning Key Laboratry of Applied Chemistry,Bohai University, Jinzhou 121000, P. R. China） ;
LIU Guo-cheng（Faculty of Chemistry and Chemical Engineering, Liaoning Key Laboratry of Applied Chemistry,Bohai University, Jinzhou 121000, P. R. China） ; |
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| 基金项目： | Supported by the Natural Science Foundation of Liaoning Province, China（No.20061073） and Education Committee Foundation of Liaoning Province, China（No.22004F023）. |
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| 摘 要： | A new dinuclear complex, Ag（L）（CH3CN）]2（ClO4）2·2H2O（L=2,3-di-2-pyridylquinoxaline）, was prepared and characterized by elemental analyses, IR spectroscopy, and single-crystal X-ray diffraction analyses. The interaction of the complex with calf thymus DNA（CT-DNA） was investigated by absorption, fluorescence spectroscopies, and viscosity measurement. The results suggested that the complex was bound to DNA via an intercalative mode. The intrinsic binding constant value Kb was found to be approximately 1.48×10^3 L·mol^-1. Moreover, the Ag（I） complex could cleave the plasmid pUC19 DNA from the supercoiled Form Ⅰto the nicked FormⅡ under irradiation at 365 nm.
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| 关 键 词： | 分析方法 化学特性 DNA 脱氧核糖核酸 |
| 收稿时间： | 2007-05-14 |
| 修稿时间： | 2007-08-20 |
Synthesis, DNA-binding, and Photocleavage of 2,3-Di-2-pyridylquinoxaline-silver(I) Complex |
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| WANG Xiu-li FANG Jia-ni BI Yan-feng LIN Hong-yan LIU Guo-cheng.Synthesis, DNA-binding, and Photocleavage of 2,3-Di-2-pyridylquinoxaline-silver(I) Complex[J].Chemical Research in Chinese University,2008,24(1):15-19. |
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| Authors: | Xiu-li WANG Jia-ni FANG Yan-feng BI Hong-yan LIN Guo-cheng LIU |
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| Institution: | aFaculty of Chemistry and Chemical Engineering, Liaoning Key Laboratry of Applied Chemistry, Bohai University, Jinzhou 121000, P. R. China |
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| Abstract: | A new dinuclear complex, Ag(L)(CH3CN)]2(ClO4)2 2H2O(L=2,3-di-2-pyridylquinoxaline), was prepared and characterized by elemental analyses, IR spectroscopy, and single-crystal X-ray diffraction analyses. The interaction of the complex with calf thymus DNA(CT-DNA) was investigated by absorption, fluorescence spectroscopies, and viscosity measurement. The results suggested that the complex was bound to DNA via an intercalative mode. The intrinsic binding constant value Kb was found to be approximately 1.48×103 L·mol−1. Moreover, the Ag(I) complex could cleave the plasmid pUC19 DNA from the supercoiled Form I to the nicked Form II under irradiation at 365 nm. |
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| Keywords: | DNA Ag-Polypyridyl complex Interaction Fluorescence Cleavage |
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