Prevalent Behavior of Strongly Order Preserving Semiflows

Classical results in the theory of monotone semiflows give sufficient conditions for the generic solution to converge toward an equilibrium or toward the set of equilibria (quasiconvergence). In this paper, we provide new formulations of these results in terms of the measure-theoretic notion of prevalence, developed in Christensen (Israel J. Math., 13, 255–260, 1972) and Hunt et al. (Bull. Am. Math. Soc., 27, 217–238, 1992). For monotone reaction–diffusion systems with Neumann boundary conditions on convex domains, we show the prevalence of the set of continuous initial conditions corresponding to solutions that converge to a spatially homogeneous equilibrium. We also extend a previous generic convergence result to allow its use on Sobolev spaces. Careful attention is given to the measurability of the various sets involved.     

Estimating vaccine coverage by using computer algebra

Email: altmannd{at}rki.deEmail: altmann{at}mathematik.hu-berlin.de The approach of N Gay for estimating the coverage of a multivalentvaccine from antibody prevalence data in certain age cohortsis complemented by using computer aided elimination theory ofvariables. Hereby, Gay's usage of numerical approximation canbe replaced by exact formulae which are surprisingly nice, too.     

Embedology

Mathematical formulations of the embedding methods commonly used for the reconstruction of attractors from data series are discussed. Embedding theorems, based on previous work by H. Whitney and F. Takens, are established for compact subsetsA of Euclidean space R^k. Ifn is an integer larger than twice the box-counting dimension ofA, then almost every map fromR ^k toR ⁿ , in the sense of prevalence, is one-to-one onA, and moreover is an embedding on smooth manifolds contained withinA. IfA is a chaotic attractor of a typical dynamical system, then the same is true for almost everydelay-coordinate map fromR ^k toR ⁿ . These results are extended in two other directions. Similar results are proved in the more general case of reconstructions which use moving averages of delay coordinates. Second, information is given on the self-intersection set that exists whenn is less than or equal to twice the box-counting dimension ofA.     

分组检测方法综述

分组检测是一种经济且有效的检测算法。它在流行病学、农业及基因组学等领域有着广泛的应用。本文主要从分组检测的起源、发展及其应用着手,着重于介绍分组检测算法中的统计推断方法,并讨论了目前分组检测算法面临的一些问题和挑战。     

食盐与高血压发病

限盐被许多国家推荐作为一项降压措施,但盐与血压之间存在复杂的相关关系。从原发性高血压的危险因素、食盐与血压的关系,以及盐-血压关系分布模式3个方面综述了食盐在高血压发病中的地位。     

ARMS TaqMan real-time PCR for genotyping factor V Leiden mutation in Han Chinese

Factor V Leiden (FV_Leiden) is a missense mutation of 1691 position (G1691A) in exon 10 of FV gene, and being a genetic risk for venous thrombosis. Currently, there are several PCR-based methods for detecting FV_Leiden mutation; however, these methods have disadvantages such as time-consuming, cumbersome steps and potentially hazardous gels. The aims of present study were to develop a simple, time-saving, accurate, and gel-free method, called amplification refractory mutation system (ARMS) TaqMan real-time PCR, for detecting FV_Leiden mutation. We severally designed two specific reverse primers for mutant and wild-type through intentional introduction of mismatched nucleotide at the penultimate 3′ position. Although target amplicon amplification efficiency is reduced, but another corresponding amplicon is almost completely inhibited. Then, specific TaqMan-probe was designed to detect target amplicon. Established method was used to detect 500 unselected samples in Han Chinese, the results showed 499 cases of wild-type and one heterozygote. Afterward, 50 randomly picked wild-type cases and one heterozygote were reexamined by bidirectional DNA sequencing, which is considered as “Gold standard method.” Exhilaratingly, the results detected by the two methods were completely consistent. At last, allelic frequency of FV_Leiden was calculated the in Han Chinese. Given the above results, A FV_Leiden heterozygote has been found in 500 random samples in Han Chinese, and the allelic frequency was 0.1%. In conclusion, the ARMS TaqMan real-time PCR is an ideal detecting system for genotyping FV_Leiden mutation in clinical application, and FV_Leiden mutation exists in Han Chinese despite extremely low prevalence.     

Seasonal trend of Anisakidae infestation in South Mediterranean bluefish

Abstract

A total of 1104 fish samples from markets of Sicily were analysed for the detection and species identification of Anisakidae nematodes. The preliminary analysis of the fish samples showed the presence of 2459 larvae. All the fish species revealed different prevalence of infestation, with a maximum of 100% for Lepidopus caudatus and a minimum of 4.5% in Sardina pilchardus. The 80% of the larvae examined by PCR-RFLP analysis belonged to Anisakis pegreffii species. The seasonal infestation trend of Anisakis was evaluated in all the fish sample examined. The results of the seasonal infestation trend showed a marked connection with the ecological aspects of the fish species examined. As far as we know, this work report for the first time important ecological aspects of Lepidopus caudatus specimens of South Mediterranean. This work could be useful to plan a seasonal fishing strategy aimed at reducing the health risks related to Anisakis.     

The effect of infected external computers on the spread of viruses: A compartment modeling study

Inevitably, there exist infected computers outside of the Internet. This paper aims to understand how infected external computers affect the spread of computer viruses. For that purpose, a new virus–antivirus spreading model, which takes into account the effect of infected/immune external computers, is established. A systematic study shows that, unlike most previous models, the proposed model admits no virus-free equilibrium and admits a globally asymptotically stable viral equilibrium. This result implies that it would be practically impossible to eradicate viruses on the Internet. As a result, inhibiting the virus prevalence to below an acceptable level would be the next best thing. A theoretical study reveals the effect of different parameters on the steady virus prevalence. On this basis, a number of suggestions are made so as to contain virus spreading.     

欧洲营养风险筛查工具在内科住院患者中应用的可行性调查

目的 调查NRS2002 营养风险筛查工具用于部分内科患者的可行性及营养风险发生率在住院期间的改变。方法 对神经内科、消化内科、呼吸内科三个专科新入院且符合入选标准的180 例患者采用NRS2002 进行营养风险筛查，调查该工具的可行性及该部分患者在住院期间营养风险的变化。结果 入选患者中完全适用NRS2002 的患者比例为85.0%，评定率及完全适用率最低的均为神经内科；全部患者中，营养风险发生率从入院时的32.8%上升为出院时的38.3%，住院期间神经内科及消化内科的营养风险发生率升高，呼吸内科降低。结论 NRS2002应用于部分内科患者是可行的；医护人员应对患者在住院期间的营养风险进行监测，给予适当的干预，以降低住院期间营养风险发生率。     

Regions of prevalence in the coupled restricted three-body problems approximation

This work concerns the role played by a couple of the planar circular restricted three-body problem in the approximation of the bicircular model. The comparison between the differential equations governing the dynamics leads to the definition of region of prevalence where one restricted model provides the best approximation of the four-body model. According to this prevalence, the patched three-body problem approximation is used to design first guess trajectories for a spacecraft travelling under the Sun-Earth-Moon gravitational influence.