Fe3O4@Nico@Ag纳米催化剂催化硝基芳烃加氢（英文）

We report the fabrication and characterization of a magnetically recyclable Fe3O4@Nico@Ag catalyst for reduction reactions in the liquid phase. Fe3O4 is a magnetic core and nicotinic acid was used as the linker for Ag. The characterization was done with X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, vibrating sample magnetometry (VSM), and ultraviolet-visible spectroscopy. VSM measurements proved the super-paramagnetic property of the catalyst.     

Total synthesis of chrysamide B

We report an efficient synthesis of the dimeric trans-epoxyamide chrysamide B, recently isolated from the deep-sea-derived fungus Penicillium chrysogenum SCSIO41001. Our synthetic strategy exploits a convergent approach using solid-phase peptide synthesis for the piperazine core and a Sharpless-Katsuki epoxidation to prepare the chiral epoxyacid. The double amidation final step provides chrysamide B that was thoroughly characterized with all spectra identical to those of the natural sample. The approach was devised to facilitate the preparation of a library of analogs of chrysamide B.     

金催化剂上脂肪族硝基化合物与醛在氢气中选择还原耦合

采用TiO2上高度分散的金纳米粒子做催化剂，从脂肪族硝基化合物、醛和氢气可高选择性合成硝酮。与碳负载Pt催化剂相比，该催化体系上硝酮的选择性从50%增加到90%。其催化性能可有活性位结构、载体特性和反应条件精确调节。     

Recent progress in copper catalyzed asymmetric Henry reaction

Henry reaction is one of the most classical reactions to construct synthetically useful product nitro alcohol, which as a privileged skeleton is widely distributed in various pharmaceuticals. This review summarizes the recent progress of copper-catalyzed asymmetric Henry reaction from 2011 to 2016. The significant progress that has been made in this area will be highlighted and some of challenges that the author believes may be hindering further progress will be revealed.     

Bis(β-Difunctional) Compounds: Versatile Starting Materials for Novel Bis(Heterocycles)

New bis(β-difunctional) compounds could be prepared in good yields. Their utility as intermediates in the synthesis of novel bis(heterocycles) were also investigated.     

A Microwave‐assisted Headspace Solid‐phase Microextraction for Rapid Determination of Synthetic Polycyclic and Nitro‐aromatic Musks in Fish Samples

Rapid solvent‐free microwave‐assisted headspace solid‐phase microextraction (MA‐HS‐SPME) coupled with gas chromatography‐mass spectrometry (GC‐MS) was developed to determine synthetic polycyclic and nitro‐aromatic musks in fish samples. Four commonly used synthetic musks, galaxolide (HHCB), tonalide (AHTN), musk xylene (MX) and musk ketone (MK) were employed in the method development and validation. The parameters (microwave irradiation time, irradiation power, amount of water addition, pH value and addition of NaCl) affecting the extraction efficiency of analytes from fish slurry were systematically investigated and optimized. The best extraction conditions were achieved when the fish sample 2‐g mixed with 4‐mL methanol and 15‐mL deionized water (containing 4 g of NaCl, pH 2.0 in a 40‐mL sample‐vial) was microwave irradiated at 80 watt for 5 min. The limits of quantification (LOQ) were 0.4 to 1.2 ng/g in 2‐g of wet tissue. The precision for these analytes, as indicated by relative standard deviations, were less than 9% for both intra‐ and inter‐day analysis. Accuracy, expressed as the mean extraction recovery, was between 80 to 92%. A standard addition method was used to quantitate these four synthetic musks, and the total concentrations ranged from 2.1 to 23.1 ng/g in various fish samples.     

UV dosimeter based on polyamide woven fabric and nitro blue tetrazolium chloride as an active compound

This paper reports on the preparation and features of a UV light dosimeter composed of nitro blue tetrazolium chloride (NBT) and polyamide woven fabric. This textile dosimeter is based on the conversion reaction of NBT into formazan, which was initially examined in aerated aqueous solutions through steady state UV irradiation. Irradiated solutions change their colour as a consequence of the formation of polydisperse NBT formazan particles. This was analysed in relation to the absorbed dose of UV light through UV–VIS spectrophotometry and dynamic laser light scattering measurements. When NBT substrate molecules are embedded in polyamide textile, UV irradiation leads to similar effects as in solution. However, the tinge intensity changes at much lower absorbed doses. The dependence of the tinge intensity on the absorbed dose was followed by measurements of the remission of light from the NBT-polyamide samples. Consequently, the calibration parameters were calculated such as the dose sensitivity, dose range, and quasi-linear dose range. An improvement of the NBT-polyamide samples by application of a colour levelling agent and improvement of their resistance to humidity is presented. Finally, the samples were used for estimation of absorbed UV energy distribution showing their capability as new dosimeters for in-plane high resolution radiation dose measurements.     

Regiospecific Preparation of 5-Acylaminotetralones

A Beckmann Rearrangement/Friedel-Crafts strategy was utilized to prepare 5-amidotetralones in high yield.     

Biotransformation of musk xylene in trout haemoglobin: dose–response and toxicokinetics of musk xylene metabolites haemoglobin adducts by gas chromatography-mass spectrometry

Musk xylene (MX) is frequently used as a fragrance in commercial toiletries. Biotransformation of MX into 4-amino-MX (4-AMX) and 2-amino-MX (2-AMX) metabolites in rainbow trout haemoglobin (Hb) has been described. The dose–response relationship and toxicokinetics of the metabolites as adducts in the Hb were determined by gas chromatography (GC)–electron capture negative chemical ionization (NCI)–mass spectrometry (MS), and GC–electron ionization (EI)–MS/MS, using selected ion monitoring (SIM). The trout were subjected to a single exposure of 0.010, 0.030, 0.10, and/or 0.30?mg?MX/g of fish. Hb samples were collected from exposed and control fish, and analysed subsequent to exposure at intervals of 24, 72, and 168?h. Alkaline hydrolysis released 4-AMX and 2-AMX metabolites from the Hb, and the solutes were extracted into n-hexane. The extracts were preconcentrated and analysed. The presence of the metabolites in the Hb extracts was confirmed based on agreement of similar mass spectral features from NCI/MS and EI-MS/MS spectra, and retention times of the metabolites with standards. The NCI/MS results were used for dose–response and toxicokinetics measurements. For dose–response, the concentrations of adducts of the metabolites increased with dosage, and a maximum adduct formation was observed at 0.10?mg?g^?1, beyond which it decreased. The average concentrations of 4-AMX and 2-AMX at a dosage of 0.10?mg?g^?1 were 700 and 7.4?ng?g^?1, respectively. For toxicokinetics, the concentration of the metabolites in the Hb reached a maximum in the 3 day sample after administration of MX. Further elimination of the metabolites exhibited kinetics with a half-life estimated to be 1–2 days, assuming first-order kinetics. Quantitations were made based on an internal standard and a calibration plot. In control samples, non-hydrolysed Hb, and reagent blank extracts, the metabolites were not detected. The limits of detection for 4-AMX and 2-AMX in the Hb were approximately 1.7 and 1.4?µg?L^?1, respectively, based on a signal-to-noise ratio of 3 with NCI/MS.