Noninvasive imaging of kidney clearance kinetics (KCK) of renal clearable probes is key to studying unilateral kidney function diseases, but such imaging is highly challenging to achieve with in vivo fluorescence. While this long‐standing challenge is often attributed to the limited light penetration depth, we found that rapid and persistent accumulation of conventional dyes in the skin “shadowed” real fluorescence signals from the kidneys and prevented noninvasive imaging of KCK, which, however, can be addressed with renal clearable nanofluorophores. By integrating near infrared emission with efficient renal clearance and ultralow background interference, the nanofluorophores can increase kidney‐contrast enhancement and imaging‐time window by approximately 50‐ and 1000‐fold over conventional dyes, and significantly minimize deviation between noninvasive and invasive KCK, laying down a foundation for translating in vivo fluorescence imaging in preclinical noninvasive kidney function assessments. 相似文献
The optimum design of the cylindrical outer contours of a gas journal bearing is obtained using the methods of the calculus of variations with allowance for the lubricant leakage through the bearing ends and the feeder slot when the lubricant mass in the working gap is conserved. The variational problem of designing the clearance shape giving the maximum bearing load capacity is formulated and solved. A modified Elrod-Burgdorfer condition for the pressure is used. 相似文献
Results of solutions to the equations governing the clearance of smoke in laminar and in turbulent flow from a single rectilinear room are presented fof five different vent arrangements. These results show that the average smoke concentration in the room decreases in an approximately exponential manner with time at a rate that depdends much more on room geometry (vent positions in the present case) than on whether the flow is laminar or turbulent. The benefit of this observation is that, provided the clearance air jet is disrupted by impingement on a solid surface within the room, the analysis of smoke movement can for many practical purposes be limited to consideration of laminar flow only. An exceptional case is when the jet is allowed to take a straight line path between the inlet and outlet vents. Here in the absence of the large scale eddies caused by jet impingement, the smaller scale eddies of turbulent flow become relatively important as a mixing mechanism and give higher clearance rates than in laminar flow. Even so, this type of geometry is best avoided. The appearance of the jet is shown in a graphic presentation of the numerical results for laminar flow. 相似文献
Low to medium pressure rise axial fan equipment of the arbitrary vortex flow rotor-only type is widely used in industrial and commercial applications, with many of the installations and rotor designs being far from optimum. Complex computational methods exist for analyzing flows in, for example, high-speed axial flow compressors with multistage blade rows; however, the designers and manufacturers of low-speed, general-purpose axial flow fan equipment have been reluctant to embrace this technology. A simpler yet reliable design technique is presented that allows this category of ducted axial fan rotors, in the presence of swirl-free inlet flow, to be designed to achieve a specified duty with sufficient accuracy for engineering purposes. Practical blade design recommendations and limits, similar to those that exist for free vortex flow axial rotors, have been established for the arbitrary vortex flow rotor-only case.
The technique employs a straightforward engineering approach to arbitrary vortex flow axial fan rotor design, and the equation set can be solved by using relatively simple numerical methods. Estimates of pressure rise and shaft power characteristics for a proposed fan/rotor design can be computed and the design loop iterated until an acceptable set of blade parameters is identified. It is also possible to analyze the performance of an existing axial fan installation as a prelude to the design of a more efficient and effective replacement rotor.
Experimental data used in validating the design and analysis techniques are also presented. These data include comprehensive Cobra pressure probe surveys of local flow parameters downstream of three different low boss ratio, low solidity, arbitrary vortex flow rotors (all with circular arc camber line type blades) as well as fan performance characteristics for one of the experimental rotors configured as a direct-exhaust fan unit. Installation-dependent factors such as direct-exhaust losses and tip clearance effects are also examined. The analytical technique is shown to provide acceptable estimates of fan/rotor pressure rise performance and shaft power characteristics over a moderately wide range of blade angles and operating conditions. 相似文献
By means of ink trace visualization of the flows in conventional straight, positively curved and negatively curved cascades
with tip clearance, and measurement of the aerodynamic parameters in the transverse section, and by appling topology theory,
the structures on both endwalls and blade surfaces were analyzed. Compared with conventional straight cascade, blade positive
curving eliminates the separation line of the upper passage vortex and leads the secondary vortex to change from close separation
to open separation, while blade negative curving effects merely the positions of singular points and the intensities and scales
of vortex.
Foundation items: 973 Project of China; the Doctoral Foundation of Education Ministry of China (EDAF24403003)
Biography: YANG Qing-hai (1969−) 相似文献
We developed and validated a high‐resolution liquid chromatography mass spectrometry method for the quantification of furosemide in camel plasma which was used for a pharmacokinetic study in camels. Plasma samples were extracted by supported liquid extraction and furosemide and internal standard (furosemide‐D5) were separated on a an Agilent Zorbax XDB C18 column (50 × 2.1 mm i.d., 3.5 μm). Data was acquired in full‐scan mode over a mass range of 200–400 Da in negative electrospray mode at a resolution of 70,000. Linear calibration curves were obtained over the concentration ranges of 1.0–10,000 ng/mL. The validated method was then successfully applied in evaluating the pharmacokinetics and metabolites of furosemide in six camels (Camelus dromedarus ) and we were able to advice on a withdrawal time of furosemide treatment before racing. 相似文献
A large clearance TiO2 nanotube arrays (LTAs) has been synthesized by a not more than 12 h anodization duration and based on this a branched TiO2 nanotube arrays (BLTs) has been achieved through TiO2 nanorods branch-like grown on the LTAs. Some key factors and probable mechanisms of the fabrication processes on two novel nanoarchitectures are discussed. Exhilaratingly, it is found that the obtained LTAs has demonstrated large pore diameter and void spaces (pore diameter ∼350 nm; void spaces ∼160 nm; and tube length ∼3.5 μm), and the synthesized hierarchical BLTs, compared with conventional TiO2 nanotube arrays, has shown a much stronger dye absorption performance and an approximately double of the solar cell efficiency (in our case from 1.62% to 3.18% under simulated AM 1.5 conditions). 相似文献
In this paper ultimate dynamics of the five-dimensional cancer tumor growth model at the angiogenesis phase is studied. This model elaborated by Pinho et al. in 2014 describes interactions between normal/cancer/endothelial cells under chemotherapy/anti-angiogenic agents in tumor growth process. The author derives ultimate upper bounds for normal/tumor/endothelial cells concentrations and ultimate upper and lower bounds for chemical/anti-angiogenic concentrations. Global asymptotic tumor clearance conditions are obtained for two versions: the use of only chemotherapy and the combined application of chemotherapy and anti-angiogenic therapy. These conditions are established as the attraction conditions to the maximum invariant set in the tumor free plane, and furthermore, the case is examined when this set consists only of tumor free equilibrium points. 相似文献