Simultaneous GC determination of turpentine, camphor, menthol and methyl salicylate in a topical analgesic formulation (Dologex®)

Summary A gas chromatographic assay has been developed for the simultaneous quantitative determination of turpentine, camphor, methol and methyl salicylate in a topical formualtion (Dologex^?). Eucalyptol was used as the internal standard. Compounds were separated on a cross-linked 5% phenyl polydimethylsiloxane capillary column and detected by FID. The method was validated on the basis of selectivity, recovery, linearity, precision and accuracy. Calibration graphs were linear for each analyte in the range studied. Intra and inter-day precision (coefficient of variation,CV) did not exceed 2%. The applicability of the method was demonstrated in a stability study of these compounds in samples of the formulation which had been maintained under different temperature conditions for six months.     

Determination of sample sizes for setting β-content tolerance limits controlling both tails of the normal distribution

The problem of determining sample size for two-sided-β-content tolerance intervals which control both tails of the normal distribution is investigated. The tolerance limits are defined to assure that the tail proportions do not exceed specified values p₁ and p₂. We determine the minimum sample size so that, at a given confidence level, the tail proportions will not be too small, i.e., so that the tolerance interval will not be overly conservative. Tables of the sample size n and the corresponding factors are provided.     

气相色谱—质谱法研究松节油直接催化异构—歧化反应

采用气相色谱-质谱联用(GC-MS)技术,对120℃时Pd/C-H2SO4协同催化松节油直接异构-歧化反应产物进行分析鉴定,共分离出45个峰,初步鉴定出37个化合物,其中主要产物为单环单萜烃对伞花烃和双环单萜烃蒈烷;主要副产物为莰烯、葑醇、苧烯、莰醇、顺式-1-甲基-4-(1-甲乙基)-环己烯醇、蒈烯、异龙脑、对孟烷-8-醇及2,6-二甲基-2-辛烯等;其相对质量分数分别为:51.42%、27.62%、4.65%、2.29%、2.28%、1.25%、0.46%、0.38%、0.37%、0.35%及0.33%。分析结果表明,在松节油直接催化异构-歧化反应过程中,其主要成分双环单萜蒎烯的异构及分子间氢转移歧化反应为主反应,并伴随深度开环异构、水合重排等副反应,倍半萜几乎不发生反应,蒎烯转化率为99.14%,对伞花烃选择性为57.46%。     

快速分析松脂澄清脂液中松节油含量的新方法

本文用统计方法研究思茅松松脂澄清脂液中松节油含量与酸值的相关关系，建立了不同于通常所用蒸馏法的新分析方法──酸值法。新方法快速、简捷、准确、经济、缩短分析时间５０分钟（７１％）；重复试验的极差的均值为０．１％，降低分析成本７０％；已用于云南省地方标准。     

Design,synthesis and evaluation of novel cis-p-menthane type Schiff base compounds as effective herbicides

p-Menthane type monoterpene derivatives were identified as bio-based compounds with high herbicidal activities. In order to search novel p-menthane type monoterpene derivatives in good performance, a series of novel cis-p-menthane type Schiff base derivatives were designed and synthesized. All target products were easily available novel compounds and characterized by FT-IR, ¹H NMR, ¹³C NMR and ESI⁺- MS. Their pre-emergence herbicidal activities against annual ryegrass were evaluated. The bioassays indicated that most of the target compounds displayed excellent herbicidal activities in pre-emergence treatment.     

脂松节油及其主要衍生物的红外光谱特征

本文以脂松节油为原料合成了几种具有代表性的衍生物，并分析和比较了脂松节油及其衍生物的红外光谱特征。