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《Macromolecular bioscience》2018,18(3)
Despite great progress, it is still of high interest to explore new homogeneous assays for simple, visual, and selective protein detection. Herein, one new colorimetric sensor has been developed for visual detection of protein by using polymeric micelles as a sensing scaffold and the molecular recognition between protein and the ligand on the surface of the polymeric micelles as the driving force to trigger the readout of the detection signal. The polymeric micelles formed via the self‐assembly of the amphiphilic block polymer biotin‐labeled poly(ethylene glycol)‐block‐poly(3‐acryl aminophenylboronic acid) are endowed with colorful feature by incorporation of alizarin red S (ARS) into the hydrophobic core. Based on the response to streptavidin recognition, these micelles are further disintegrated through the competitive binding of α‐cyclodextrin with boronic acid for disassociation of ARS, which achieves orange–yellow to pink–purple transition in 2 h. This work will open the way to develop one new mix‐and‐measure, visual, and homogeneous assay. 相似文献
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Ruibing An Xiaoyang Cheng Shixuan Wei Yuxuan Hu Yidan Sun Zheng Huang Prof. Hong-Yuan Chen Prof. Deju Ye 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(46):20817-20825
Stimuli-responsive smart photosensitizer (PS) nanoassemblies that allow enhanced delivery and controlled release of PSs are promising for imaging-guided photodynamic therapy (PDT) of tumors. However, the lack of high-sensitivity and spatial-resolution signals and fast washout of released PSs from tumor tissues have impeded PDT efficacy in vivo. Herein, we report tumor targeting, redox-responsive magnetic and fluorogenic PS nanoassemblies ( NP-RGD ) synthesized via self-assembly of a cRGD- and disulfide-containing fluorogenic and paramagnetic small molecule ( 1-RGD ) for fluorescence/magnetic resonance bimodal imaging-guided tumor PDT. NP-RGD show high r1 relaxivity but quenched fluorescence and PDT activity; disulfide reduction by glutathione (GSH) promotes efficient disassembly into a small-molecule probe ( 2-RGD ) and an organic PS (PPa-SH), which could further bind with intracellular albumin, allowing prolonged retention and cascade activation of fluorescence and PDT to ablate tumors. 相似文献
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Suhrit Ghosh Volkan Yesilyurt Elamprakash N. Savariar Katharine Irvin S. Thayumanavan 《Journal of polymer science. Part A, Polymer chemistry》2009,47(4):1052-1060
Formation of micelle‐type assembly from supramolecular complexation of a surfactant and an oppositely charged homopolymer is demonstrated. The lower CAC observed for these assemblies suggest that the electrostatic interaction provides an amphiphilic homopolymer‐like structure. The stimulus‐induced disassembly of these supramolecular structures has been accomplished with variations in redox characteristics, ionic strength, and pH of the medium. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 1052–1060, 2009 相似文献
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Dr. Mengjiao Cheng Prof. Feng Shi 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(68):15763-15778
Macroscopic supramolecular assembly (MSA) is a new concept in supramolecular science with a focus on interfacial assembly of macroscopic building blocks, which has largely extended the applicable materials of supramolecular assembly and provided new solutions to fabricating tissue scaffolds, soft devices, etc. The precision of the assembled structures is of great interest; unlike molecular assemblies, MSA precision is highly dependent on the matching degree of assembled surfaces because of the large interactive area and group number, which result in remarkably increased kinetic possibilities and metastable assemblies. This Concept introduces the principle, history, and development of MSA, elaborates the low-precision challenge in MSA, summarizes the strategies for precise MSA based on the different thermodynamic stability of precise/imprecise structures and control over assembly kinetics, and finally demonstrates the applications of precise MSA structures in advanced manufacture such as tissue scaffolds. 相似文献
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Q.W. Yang 《Applied mathematics and computation》2009,215(7):2775-2780
A computationally attractive method is proposed in this study to provide an insight to the location and extent of structural damage. The proposed method makes use of the matrix disassembly technique and approaches the damage location and extent problem in a decoupled fashion. First, a scheme is developed to determine the damage location by calculating a damage localization vector, which is derived from the modal residual force criteria. With location determined, the corresponding damage extent can be easily obtained only by the processes of division. The algorithm is applied to a numerical example and its efficiency is demonstrated through damage simulations. 相似文献
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RAO Yi-Jian YUAN Cai BIAN Chuan-Bing HOU Xiao-Min LI Yong-Dong ZHAO Geng-Xiang YE Xiao-Ming HUANG Zi-Xiang HUANG Ming-Dong ② 《结构化学》2006,25(7):854-860
1 INTRODUCTION The selective export of cargoes from the endore- ticulum is an evolutionarily conserved function cen- tral to cell development and proliferation. This ex- port is regulated by the Sar1 GTPase, a member of the Ras superfamily of small GTPases[1~4]. Like other Ras proteins, Sar1 functions as binary switches by cycling between inactive GDP- and active GTP- bound states[5]. The conversion of Sar1-GDP to Sar1- GTP following receptor activation is catalyzed by guanine nu… 相似文献