Syntheses of Aladan and [Ald~6](?)oloatin C and Study on Their Fluorescent Properties

Aladan{β-[6'-(N,N-dimethyl)amino-2'-naphthoyl]alanine}and aladan-containing cyclodecapeptide[Ald~6]-loloatin C were synthesized.The properties of their fluorescent behaviours both in aqueous buffer and micelles cre-ated by sodium dodecylsulfate(SDS)and dodecylphosphorylcholine(DPC)were further investigated.It was foundthat in either of micelle systems,[Ald~6]loloatin C possesses red-shift emission maximum wavelength and higherquantum yield.This property could be useful in the research of peptide-cell membrane interaction.     

Aladan scanning: The structure-activity relationship of dynorphin A

An unnatural amino acid, β-[6′-(N, N-dimethyl)amino-2′-naphthoyl]alanine (Ald) showing polarity-sen sitive fluorescence characteristics, was synthesized. A thorough Ald-scan of dynorphin A (Dyn A), the putative endogenous ligand for κ opioid receptors, was then performed. Replacement of the amino acid residues in positions 5, 8, 10, 12 or 14 of Dyn A(1-13)-NH2 with Ald resulted in compounds that had almost equal κ binding affinity compared with that of the parent compound; on the other hand, substi-tution o...     

Syntheses of Aladan and [Ald^6]loloatin C and Study on Their Fluorescent Properties

Aladan {β-[6＇-（N,N-dimethyl）amino-2＇-naphthoyl]alanine} and aladan-containing cyclodecapeptide [Ald^6]loloatin C were synthesized. The properties of their fluorescent behaviours both in aqueous buffer and micelles created by sodium dodecylsulfate （SDS） and dodecylphosphorylcholine （DPC） were further investigated. It was found that in either of micelle systems, [Ald^6]loloatin C possesses red-shift emission maximum wavelength and higher quantum yield. This property could be useful in the research of peptide-cell membrane interaction.