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高效液相色谱法测定血浆中7种灭鼠剂 总被引:12,自引:0,他引:12
建立了血浆中7种缓效灭鼠剂的反相高效液相色谱分析方法,选择了样品提取与测定条件,考察了有关化合物对测定的影响,在色谱工作站上建立了灭鼠剂的紫餐吸收光谱库,根据吸收光谱与tR值进行库检索,提出了定性的准确度。方法的线性范围为2-10μL/L血浆,最低检测浓度为1μL/mL血浆。 相似文献
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亲水性材料固相萃取-紫外导数光谱法检测血中茚满二酮灯抗凝 … 总被引:6,自引:1,他引:5
本文报导了血中茚满二酮类抗凝血杀鼠剂敌鼠、氯敌鼠、杀鼠酮的亲水性材料固相萃取-紫外导数光谱检测法。血样用pH5缓冲液等体积稀释后加于西雷脱硅藻土柱上,柱用乙酸乙 酯洗脱,将洗脱液挥发干净,剩余物用pH10缓冲液溶解,测定所得溶液的二阶导数光谱进行定性和定量分析。三种杀鼠剂以10mg/L的量加于空白血中测得萃取率为85%以上,血中三种杀鼠剂的检出限低于2mg/L。萃取中亲水性硅藻土可用硅胶和氧化铝代替, 相似文献
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The increase of pest rodents population in urban and rural areas is tackled by dissemination of baits poisoned with anticoagulant compounds. In order to modelize the cell membrane transport of these rodenticides, which have toxic effect on human keratynocytes and break the vitamin K cycle, a new general model based on the perturbation method was developed to describe the association process between these rodenticide and an immobilized artificial membrane (IAM). The thermodynamic functions of the rodenticide transfer from the bulk solvent to the IAM surface were also determined. The variation plots of the solute transfer data versus the salt concentration (x) in the bulk solvent allow to demonstrate that the rodenticides—IAM surface association mechanism was governed by both the hydrophobic effect and the van der Waals interactions/hydrogen bonds between the rodenticide polar groups with the polar headgroups of phospholipid monolayers (polar retention effect). This result was also corroborated by a comparison of the number of water molecules surrounded the rodenticide in the medium (obtained by computational chemistry) and the number of water molecule release at the IAM—rodenticide interface (obtained thanks to the Tanford's equation). 相似文献
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《Analytical letters》2012,45(13-14):2813-2834
Abstract Spectrophotometric procedure is described for the quantitative determination of diphenadione [2-(diphenylacetyl)-1,3-indandione], based on direct spectrophotometric measurements of the absorbances of its iron (III), iron (II) and cobalt (II), metal complexes at 488 nm, 505 nm and (334 nm, 372 nm), respectively. The drug reacts with metals in the ratio of 3:1 and 2:1 for iron (III) and for both iron (II) and cobalt (II) respectively. The obtained complexes have apparent molar absorptivities of 1.48 × 103 1 mol?1 cm?1, 0.714 × 103 1 mol?1cm?1 and (1.70 × 103 1 mol?1cm?1, 1.93 × 103 1 mol?1cm?1) for iron (III), iron (II) and cobalt (II) complexes, respectively. The procedure is suggested for the determination of 51–400 μg.ml?1 diphenadione via the iron (II) complex and 35–170 μg.ml?1 diphenadione via both cobalt (II) and iron (III) complexes. The suggested procedure has accuracies of 99.79 ± 0.67%, 99.64 ± 0.37% and (100.09 ± 0.53%, 99.99 ± 0.42%) for the metal complexes of iron (III), iron (II) and cobalt (II), respectively. 相似文献
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